Y
Yongkui Jing
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 110
Citations - 4755
Yongkui Jing is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Apoptosis & Acute promyelocytic leukemia. The author has an hindex of 35, co-authored 100 publications receiving 4405 citations. Previous affiliations of Yongkui Jing include Mount Sinai Hospital & Peking Union Medical College.
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Journal ArticleDOI
Malignant Cells Can Be Sensitized to Undergo Growth Inhibition and Apoptosis by Arsenic Trioxide Through Modulation of the Glutathione Redox System
TL;DR: Ascorbic acid enhanced the antilymphoma effect of As2O3 in vivo without additional toxicity, and may provide a novel therapy for lymphoma.
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Arsenic Trioxide Selectively Induces Acute Promyelocytic Leukemia Cell Apoptosis Via a Hydrogen Peroxide-Dependent Pathway
TL;DR: It is shown that the ability of As2O3 to induce apoptosis in leukemic cells is dependent on the activity of the enzymes that regulate cellular H2O2 content, and NB4 cells have relatively low levels of glutathione peroxidase (GPx) and catalase and have a constitutively higher H 2O2content than U937 monocytic leukemia cells.
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Apoptosis and Growth Inhibition in Malignant Lymphocytes After Treatment With Arsenic Trioxide at Clinically Achievable Concentrations
Xin-Hua Zhu,Y. Shen,Yongkui Jing,Xun Cai,Pei-Ming Jia,Ying Huang,Wei Tang,Gui-Ying Shi,Yueping Sun,Jie Dai,Zhen-Yi Wang,Sai-Juan Chen,Ting-Dong Zhang,Samuel Waxman,Zhu Chen,Guo-Qiang Chen +15 more
TL;DR: Substantial growth inhibition and apoptosis without evidence of differentiation were induced in most malignant lymphocytic cells treated with 1-2 μM As 2 O 3, which may prove useful in the treatment ofmalignant lymphoproliferative disorders.
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Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo.
Yongkui Jing,Long Wang,Long Wang,Lijuan Xia,Lijuan Xia,Guo-Qiang Chen,Guo-Qiang Chen,Zhu Chen,Zhu Chen,Wilson H. Miller,Wilson H. Miller,Samuel Waxman,Samuel Waxman +12 more
TL;DR: Combined As(2)O(3) and tRA treatment may be more effective than single agents in tRA-resistant patients, and toxicity and potential drug antagonism may be diminished when given at the same time with therapeutic levels of tRA.
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Antineoplastic Agents III: Steroidal Glycosides from Solanum nigrum
TL;DR: The cytotoxic assay indicated that 2 is the main antineoplastic agent in S. nigrum, and the structures of 1-3 were elucidated on the basis of chemical evidence and spectral analysis, especially by 2D-NMR analysis.