S
Samuel Waxman
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 209
Citations - 19430
Samuel Waxman is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Acute promyelocytic leukemia & Cellular differentiation. The author has an hindex of 65, co-authored 204 publications receiving 18177 citations. Previous affiliations of Samuel Waxman include McGill University & Mount Sinai Hospital.
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Journal Article
Mechanisms of action of arsenic trioxide.
TL;DR: Substantial data show that arsenic trioxide produces remissions in patients with APL at least in part through a mechanism that results in the degradation of the aberrant PML-retinoic acid receptor alpha fusion protein.
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Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) : I. As2O3 exerts dose-dependent dual effects on APL cells
Guo-Qiang Chen,Xue-Geng Shi,Wei Tang,Shu-Min Xiong,Jun Zhu,Xun Cai,Ze-Guang Han,Jian-Hua Ni,Gui-Ying Shi,Pei-Ming Jia,Meng-Min Liu,Kai-Li He,Chao Niu,Jun Ma,Peng Zhang,Ting-Dong Zhang,Pascale Paul,Tomoki Naoe,Kunio Kitamura,Wilson H. Miller,Samuel Waxman,Zhen-Yi Wang,Sai-Juan Chen,Zhu Chen +23 more
TL;DR: Combination of induction of apoptosis and partial differention could be the main cellular mechanisms of As2O3 in the treatment of APL, and PML-RAR alpha could play an important role in determining the specific effects of As 2O3 on APL cells.
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Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma
Augusto Villanueva,Derek Y. Chiang,Pippa Newell,Judit Peix,Swan N. Thung,Clara Alsinet,Victoria Tovar,Sasan Roayaie,Beatriz Minguez,Manel Solé,Carlo Battiston,Stijn van Laarhoven,Maria Isabel Fiel,Analisa Di Feo,Yujin Hoshida,Steven Yea,Sara Toffanin,Alex H. Ramos,John A. Martignetti,Vincenzo Mazzaferro,Jordi Bruix,Samuel Waxman,Myron Schwartz,Matthew Meyerson,Scott L. Friedman,Josep M. Llovet,Josep M. Llovet +26 more
TL;DR: MTOR signaling has a critical role in the pathogenesis of HCC, with evidence for the role of RICTOR in hepato-oncogenesis, and a rationale for targeting the mTOR pathway in clinical trials in HCC is established.
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Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma
Elisa Wurmbach,Yingbei Chen,Greg Khitrov,Weijia Zhang,Sasan Roayaie,Myron Schwartz,Isabel Fiel,Swan N. Thung,Vincenzo Mazzaferro,Jordi Bruix,Erwin P. Bottinger,Scott L. Friedman,Samuel Waxman,Josep M. Llovet +13 more
TL;DR: A comprehensive molecular portrait of genomic changes in progressive HCV‐related HCC is provided, using quantitative real‐time reverse‐transcription PCR to identify new biomarkers for early HCC diagnosis.
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Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.
Zhu Chen,Nigel J. Brand,Alex T. Chen,Sai Juan Chen,Jian-Hua Tong,Zhen Yi Wang,Samuel Waxman,Arthur Zelent +7 more
TL;DR: The results demonstrate for the first time the association of a variant chromosomal translocation involving the Rar alpha gene with APL, further implicating the RAR alpha in leukaemogenesis and also suggesting an important role for PLZF as well as retinoic acid and its receptors in myeloid maturation.