Y
Yongsoo Kim
Researcher at Pennsylvania State University
Publications - 54
Citations - 2685
Yongsoo Kim is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 18, co-authored 42 publications receiving 1942 citations. Previous affiliations of Yongsoo Kim include Northwestern University & Cold Spring Harbor Laboratory.
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Journal ArticleDOI
Serial two-photon tomography for automated ex vivo mouse brain imaging
Timothy Ragan,Lolahon R. Kadiri,Kannan Umadevi Venkataraju,Karsten Bahlmann,Jason Sutin,Julian Taranda,Ignacio Arganda-Carreras,Yongsoo Kim,H. Sebastian Seung,Pavel Osten +9 more
TL;DR: An automated method is described that achieves high-throughput fluorescence imaging of mouse brains by integrating two-photon microscopy and tissue sectioning, which opens the door to routine systematic studies of neuroanatomy in mouse models of human brain disorders.
Journal ArticleDOI
Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex
Miao He,Miao He,Jason Tucciarone,Jason Tucciarone,Soo Hyun Lee,Maximiliano José Nigro,Yongsoo Kim,Jesse Maurica Levine,Jesse Maurica Levine,Sean Michael Kelly,Sean Michael Kelly,Illya Krugikov,Priscilla Wu,Yang Chen,Ling Gong,Yongjie Hou,Pavel Osten,Bernardo Rudy,Z. Josh Huang +18 more
TL;DR: It is demonstrated that combinatorial genetic and viral approaches target restricted GABAergic subpopulations and cell types characterized by distinct laminar location, morphology, axonal projection, and electrophysiological properties.
Journal ArticleDOI
Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism
Yongsoo Kim,Yongsoo Kim,Guangyu Robert Yang,Kith Pradhan,Kannan Umadevi Venkataraju,Mihail Bota,Luis Carlos García del Molino,Greg Fitzgerald,Keerthi Ram,Miao He,Jesse Maurica Levine,Jesse Maurica Levine,Partha P. Mitra,Z. Josh Huang,Xiao Jing Wang,Xiao Jing Wang,Pavel Osten +16 more
TL;DR: An unexpected cortical organizing principle is discovered: sensory-motor areas are dominated by output-modulating parvalbumin-positive interneurons, whereas association, including frontal, areas aredominated by input-modifying somatostatin-positiveinterneuron areas.
Journal ArticleDOI
Mapping Social Behavior-Induced Brain Activation at Cellular Resolution in the Mouse
Yongsoo Kim,Kannan Umadevi Venkataraju,Kith Pradhan,Carolin Mende,Julian Taranda,Srinivas C. Turaga,Ignacio Arganda-Carreras,Lydia Ng,Michael Hawrylycz,Kathleen S. Rockland,Kathleen S. Rockland,H. Sebastian Seung,Pavel Osten +12 more
TL;DR: In this paper, the authors apply an automated method for mapping brain activation in the mouse in order to probe how sex-specific social behaviors are represented in the male brain using the immediate-early-gene c-fos, a marker of neuronal activation, visualized by serial two-photon tomography.
Journal ArticleDOI
Dynamic features of postnatal subventricular zone cell motility: A two-photon time-lapse study
Sang Chae Nam,Yongsoo Kim,Dilyan I. Dryanovski,Avery S. Walker,Gwendolyn E. Goings,Kevin M. Woolfrey,Seong Su Kang,Chris Chu,Anjen Chenn,Ferenc Erdélyi,Gábor Szabó,Philip E. Hockberger,Francis G. Szele +12 more
TL;DR: Cell motility in the SVZ and RMS is far more complex then previously thought and involves multiple cell types, behaviors, speeds, and directions.