Yoriko Takahashi

TL;DR: It is found that PSCA is expressed in differentiating gastric epithelial cells, has a cell-proliferation inhibition activity in vitro and is frequently silenced in gastric cancer.

TL;DR: DNA methylation profiles reflecting carcinogenetic factors such as smoking and COPD appear to be established in non‐cancerous lung tissue from patients with LADCs and may determine the aggressiveness of tumors developing in individual patients, and thus patient outcome.

TL;DR: Genome-wide DNA methylation analysis indicated thatDNA methylation alterations are already present even at the precancerous NASH stage, clearly differing from such alterations in viral hepatitis or cirrhosis, and possibly continuing to participate in NASH-related multistage hepatocarcinogenesis.

TL;DR: Data indicate that genetically and epigenetically different pathways may participate in the development of EEs and LEs, and that DNA methylation profiling may help predict tumors that are less aggressive and amenable to fertility preservation treatment.

TL;DR: The data suggest that abnormalities of the spindle checkpoint pathway participate in CIMP‐positive renal carcinogenesis, and that AURKA and AURKB may be potential therapeutic targets in more aggressive CIMp‐positive RCCs.