Yoshiko Nomura

TL;DR: The accumulating knowledge of insect sodium channels and their interactions with insecticides provides a foundation for understanding the neurophysiology of sodium channels in vivo and the development of new and safer insecticides for effective control of arthropod pests and human disease vectors.

TL;DR: The successful expression of a sodium channel, AaNav1–1, from Aedes aegypti in Xenopus oocytes, and the functional examination of nine sodium channel mutations that are associated with pyrethroid resistance in various Ae.

TL;DR: These results provide the first evidence that alternative splicing of a sodium channel gene produces pharmacologically distinct channels and exhibited a striking difference in sensitivity to a pyrethroid insecticide, deltamethrin.

TL;DR: The V410L mutation drastically reduced the sensitivity of mosquito sodium channels expressed in Xenopus oocytes to both type I and type II pyrethroids and presents a serious challenge for the control of A. aegypti in Brazil.

TL;DR: This work characterized 20 splice variants of the German cockroach sodium channel gene BgNav and provided direct evidence that RNA editing is an important mechanism generating tissue-/cell type-specific functional variants of sodium channels.