Y
Yoshinari Tanabe
Researcher at Niigata University
Publications - 62
Citations - 1458
Yoshinari Tanabe is an academic researcher from Niigata University. The author has contributed to research in topics: Pneumonia & STAT1. The author has an hindex of 18, co-authored 59 publications receiving 1224 citations. Previous affiliations of Yoshinari Tanabe include University of California, San Diego.
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Journal ArticleDOI
Cutting Edge: Role of STAT1, STAT3, and STAT5 in IFN-αβ Responses in T Lymphocytes
TL;DR: This study demonstrates that IFN-αβ, although antiproliferative in wild-type CD4+ or CD8+ T cells, act as strong mitogens on their STAT1−/− counterparts, and provides the first evidence for a function of STAT3 and STAT5A/B in the IFn- αβ response.
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Impaired Development of CD4+ CD25+ Regulatory T Cells in the Absence of STAT1 Increased Susceptibility to Autoimmune Disease
TL;DR: Adoptive transfer of wild-type regulatory T cells into STAT1-deficient hosts is sufficient to prevent the development of autoimmune disease and demonstrates an essential role of STAT1 in the maintenance of immunological self-tolerance.
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Efficacy of colistin combination therapy in a mouse model of pneumonia caused by multidrug-resistant Pseudomonas aeruginosa
Nobumasa Aoki,Nobumasa Aoki,Kazuhiro Tateda,Yoshiaki Kikuchi,Soichiro Kimura,Choichiroh Miyazaki,Yoshikazu Ishii,Yoshinari Tanabe,Fumitake Gejyo,Keizo Yamaguchi +9 more
TL;DR: Data suggest that colistin may be an important option for combination therapy against critical MDRP infections, especially for pneumonia especially, and not only for synergistic antibacterial activity, but also for blocking LPS.
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Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity
Yoshihisa Hori,Nobumasa Aoki,Shoji Kuwahara,Michihiro Hosojima,Ryohei Kaseda,Sawako Goto,Tomomichi Iida,Shankhajit De,Hideyuki Kabasawa,Reika Kaneko,Hiroyuki Aoki,Yoshinari Tanabe,Hiroshi Kagamu,Ichiei Narita,Toshiaki Kikuchi,Akihiko Saito +15 more
TL;DR: Cilastatin may be a promising agent for inhibiting various forms of drug-induced nephrotoxicity mediated via megalin in the clinical setting and efficiently suppresses the neph rotoxicity induced by gentamicin, colistin, vancomycin, or cisplatin.
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Anti-interferon-γ autoantibody in a patient with disseminated Mycobacterium avium complex
Toshiyuki Koya,Chikako Tsubata,Hiroshi Kagamu,Kenichi Koyama,Masachika Hayashi,Katsuhiro Kuwabara,Takui Itoh,Yoshinari Tanabe,Toshinori Takada,Fumitake Gejyo +9 more
TL;DR: A 44-year-old woman with disseminated Mycobacterium avium complex infection involving multiple bone lesions despite a normal healthy status until 6 months previously is reported, only the second case of disseminated MAC infection associated with anti-IFN-γ autoantibodies in Japan.