T
Toshiaki Kikuchi
Researcher at Niigata University
Publications - 236
Citations - 5328
Toshiaki Kikuchi is an academic researcher from Niigata University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 34, co-authored 209 publications receiving 4497 citations. Previous affiliations of Toshiaki Kikuchi include Tohoku University & Cornell University.
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Journal ArticleDOI
Severe acute interstitial pneumonia and gefitinib.
Akira Inoue,Yasuo Saijo,Makoto Maemondo,Kazunori Gomi,Yutaka Tokue,Yuichiro Kimura,Masahito Ebina,Toshiaki Kikuchi,Takuya Moriya,Toshihiro Nukiwa +9 more
TL;DR: Assessment of patients who had non-small cell lung cancer causing severe acute interstitial pneumonia in association with gefitinib found diffuse alveolar damage, which was consistent with acuteinterstitial pneumonia, should be aware of the alveolars damage induced by gefithinib.
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Proinflammatory Cytokine IL-1β Promotes Tumor Growth of Lewis Lung Carcinoma by Induction of Angiogenic Factors: In Vivo Analysis of Tumor-Stromal Interaction
Yasuo Saijo,Masashi Tanaka,Makoto Miki,Kazuhiro Usui,Takuji Suzuki,Makoto Maemondo,Xin Hong,Ryushi Tazawa,Toshiaki Kikuchi,Kouji Matsushima,Toshihiro Nukiwa +10 more
TL;DR: Results indicated that secreting IL-1β into the tumor milieu induces several angiogenic factors from tumor and stromal cells and thus promotes tumor growth through hyperneovascularization.
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Altered Cochlear Fibrocytes in a Mouse Model of DFN3 Nonsyndromic Deafness
Osamu Minowa,Katsuhisa Ikeda,Yoshinobu Sugitani,Takeshi Oshima,Shigeyasu Nakai,Yukio Katori,Masaaki Suzuki,Masayuki Furukawa,Tetsuaki Kawase,Y. Zheng,Masaki Ogura,Yukinori Asada,Kenichi Watanabe,Hitomi Yamanaka,S. Gotoh,S. Gotoh,M. Nishi-Takeshima,Tetsuo Sugimoto,Toshiaki Kikuchi,Tomonori Takasaka,Tetsuo Noda,Tetsuo Noda +21 more
TL;DR: The findings suggest that cochlear spiral ligament fibrocytes, which are mesenchymal in origin and for which a role in potassium ion homeostasis has been postulated, may play a critical role in auditory function.
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AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells.
Hirokazu Taniguchi,Tadaaki Yamada,Tadaaki Yamada,Rong Wang,Keiko Tanimura,Yuta Adachi,Akihiro Nishiyama,Azusa Tanimoto,Shinji Takeuchi,Luiz H. Araujo,Mariana Boroni,Akihiro Yoshimura,Shinsuke Shiotsu,Isao Matsumoto,Satoshi Watanabe,Toshiaki Kikuchi,Satoru Miura,Hiroshi Tanaka,Takeshi Kitazaki,Hiroyuki Yamaguchi,Hiroshi Mukae,Junji Uchino,Hisanori Uehara,Koichi Takayama,Seiji Yano +24 more
TL;DR: It is shown that AXL, which is activated by osimertinib, can promote the emergence of tolerant lung cancer cell thus conferring resistance to osimERTinib and proposed the combination of Osimert inib with AXL inhibitor as a potential therapeutic approach in such resistant cancers.
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Targeted delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells.
Hong Xin,Masahiko Kanehira,Hiroyuki Mizuguchi,Takao Hayakawa,Toshiaki Kikuchi,Toshihiro Nukiwa,Yasuo Saijo +6 more
TL;DR: The tropism of mouse MSCs to tumor cells in vitro and multiple tumor tissues in the lung after i.v. injection of green fluorescent protein‐positive MSCS in vivo is demonstrated and suggests that MSC's can be used as a vehicle for introducing biological agents into multiple lung tumor tissues.