Yoshio Koyanagi

TL;DR: It is suggested that multiple immunological dysfunctions, including cytokine production capability, in addition to functional incompetence of T, B, and NK cells, may lead to the high engraftment levels of xenograft in NOD/SCID/gamma(c)(null) mice.

TL;DR: Activities of HTLV-III were neutralized by the human antibodies against the virus when immunofluorescence and plaque assays were used, and the same results were obtained with the lymphadenopathy-associated virus (LAV1).

TL;DR: Results indicate that genetic variation of HIV in vivo may result in altered cell tropisms and possibly implicate strains of HIV with glial cell tropism in the pathogenesis of some neurologic disorders of AIDS.

TL;DR: It is proposed that at least one determinant for mononuclear phagocyte tropism involves target cell interactions with regions of gp120 distinct from the CD4-binding domain, and genetic mapping of the macrophage-tropic phenotype by construction of recombinant viruses indicates this region can be determined by a 157-amino-acid region of the gp120 glycoprotein of HIV-1JR–FL.

TL;DR: The potential of the CRISPR/Cas9 system to edit the HIV-1 genome and block its expression is shown and this system was also able to remove internal viral genes from the host cell chromosome.