T
Toshio Heike
Researcher at Kyoto University
Publications - 271
Citations - 12656
Toshio Heike is an academic researcher from Kyoto University. The author has contributed to research in topics: Stem cell & Induced pluripotent stem cell. The author has an hindex of 50, co-authored 267 publications receiving 11422 citations. Previous affiliations of Toshio Heike include University of Fukui & Japan Agency for Medical Research and Development.
Papers
More filters
Journal ArticleDOI
Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor
Makoto Miyara,Yumiko Yoshioka,Akihiko Kitoh,Tomoko Shima,Kajsa Wing,Akira Niwa,Christophe Parizot,Cécile Taflin,Toshio Heike,Dominique Valeyre,Alexis Mathian,Tatsutoshi Nakahata,Tomoyuki Yamaguchi,Takashi Nomura,Masahiro Ono,Zahir Amoura,Guy Gorochov,Guy Gorochov,Shimon Sakaguchi,Shimon Sakaguchi +19 more
TL;DR: The dissection of FoxP3(+) cells into subsets enables one to analyze Treg cell differentiation dynamics and interactions in normal and disease states, and to control immune responses through manipulating particular FoxP 3(+) subpopulations.
Journal ArticleDOI
NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells.
Mamoru Ito,Hidefumi Hiramatsu,Kimio Kobayashi,Kazutomo Suzue,Mariko Kawahata,Kyoji Hioki,Yoshito Ueyama,Yoshio Koyanagi,Kazuo Sugamura,Kohichiro Tsuji,Toshio Heike,Tatsutoshi Nakahata +11 more
TL;DR: It is suggested that multiple immunological dysfunctions, including cytokine production capability, in addition to functional incompetence of T, B, and NK cells, may lead to the high engraftment levels of xenograft in NOD/SCID/gamma(c)(null) mice.
Journal ArticleDOI
Generation of Pluripotent Stem Cells from Neonatal Mouse Testis
Mito Kanatsu-Shinohara,Kimiko Inoue,Jiyoung Lee,Momoko Yoshimoto,Narumi Ogonuki,Hiromi Miki,Shiro Baba,Takeo Kato,Yasuhiro Kazuki,Shinya Toyokuni,Megumi Toyoshima,Ohtsura Niwa,Mitsuo Oshimura,Toshio Heike,Tatsutoshi Nakahata,Fumitoshi Ishino,Atsuo Ogura,Takashi Shinohara +17 more
TL;DR: The successful establishment of ES-like cells from neonatal mouse testis were phenotypically similar to ES/EG cells except in their genomic imprinting pattern and differentiated into various types of somatic cells in vitro under conditions used to induce the differentiation of ES cells.
Journal ArticleDOI
Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-κB activation: common genetic etiology with Blau syndrome
Nobuo Kanazawa,Ikuo Okafuji,Naotomo Kambe,Ryuta Nishikomori,Mami Nakata-Hizume,Sonoko Nagai,Akihiko Fuji,Takenosuke Yuasa,Akira Manki,Yoshihiko Sakurai,Mitsuru Nakajima,Hiroko Kobayashi,Ikuma Fujiwara,Hiroyuki Tsutsumi,Atsushi Utani,Chikako Nishigori,Toshio Heike,Tatsutoshi Nakahata,Yoshiki Miyachi +18 more
TL;DR: Findings indicate that the majority of EOS and BS cases share the common genetic etiology of CARD15 mutations that cause constitutive NF-kappaB activation.
Journal ArticleDOI
Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/γcnull mice model
Hidefumi Hiramatsu,Ryuta Nishikomori,Ryuta Nishikomori,Toshio Heike,Toshio Heike,Mamoru Ito,Mamoru Ito,Kimio Kobayashi,Kimio Kobayashi,Kenji Katamura,Kenji Katamura,Tatsutoshi Nakahata,Tatsutoshi Nakahata +12 more
TL;DR: Results of ontogenic, functional, and histologic examination results of reconstituted human lymphocytes in NOD/SCID/ gammacnull mice after the transplantation of human cord blood (CB) CD34+ cells revealed that human lymphocyte formed organized structures in spleen and thymus that were analogous to those seen in humans.