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Youjin Hu
Researcher at University of California, Los Angeles
Publications - 9
Citations - 427
Youjin Hu is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Transcriptome & Gene. The author has an hindex of 5, co-authored 8 publications receiving 299 citations. Previous affiliations of Youjin Hu include Sun Yat-sen University & Tongji University.
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Journal ArticleDOI
Simultaneous profiling of transcriptome and DNA methylome from a single cell
Youjin Hu,Youjin Hu,Kevin Huang,Qin An,Guizhen Du,Ganlu Hu,Jinfeng Xue,Xianmin Zhu,Cun-Yu Wang,Zhigang Xue,Guoping Fan +10 more
TL;DR: In this article, a method (scMT-seq) was proposed to detect transcriptome, methylome, and single nucleotide polymorphism information within single cells to dissect the mechanisms of epigenetic gene regulation.
Journal ArticleDOI
Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons.
Ganlu Hu,Kevin Huang,Youjin Hu,Youjin Hu,Guizhen Du,Zhigang Xue,Xianmin Zhu,Guoping Fan,Guoping Fan,Guoping Fan +9 more
TL;DR: This study revealed the distinctive and sustained heterogeneity of transcriptomic responses to injury at single neuron level, implicating the involvement of different gene regulatory networks in nerve regeneration, neuronal cell death and neuropathy in different population of DRG neurons.
Additional file 1: of Simultaneous profiling of transcriptome and DNA methylome from a single cell
Youjin Hu,Kevin Huang,Qin An,Guizhen Du,Ganlu Hu,Jinfeng Xue,Xianmin Zhu,Cun-Yu Wang,Zhigang Xue,Guoping Fan +9 more
TL;DR: This work describes a novel method (scMT-seq) that simultaneously profiles both DNA methylome and transcriptome from the same cell and finds positive correlation of allelic gene body methylation with allelic expression.
Journal ArticleDOI
The size of cell-free mitochondrial DNA in blood is inversely correlated with tumor burden in cancer patients.
Qin An,Youjin Hu,Qingjiao Li,Xufeng Chen,Xufeng Chen,Jiaoti Huang,Jiaoti Huang,Matteo Pellegrini,Xianghong Jasmine Zhou,Matthew Rettig,Guoping Fan +10 more
TL;DR: Blood cfDNA samples from hepatocellular carcinoma and prostate cancer patients were analyzed and it was found that mt-cfDNA lengths were inversely related to tumor size as well as the concentration of circulating tumor DNA.
Journal ArticleDOI
The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat.
Shuyang Xu,Xianmin Zhu,Hong Li,Youtian Hu,Jinping Zhou,Di He,Yun Feng,Lina Lu,Guizhen Du,Youjin Hu,Youjin Hu,Tiancheng Liu,Zhen Wang,Guohui Ding,Jiayu Chen,Shaorong Gao,Fang Wu,Zhigang Xue,Yixue Li,Guoping Fan,Guoping Fan +20 more
TL;DR: Phenotypic study demonstrated that Lep∆I14 rats recapitulate phenotypes of Lep-null mutant rats including obesity, hyperinsulinemia, hepatic steatosis, nephropathy, and infertility.