Yu Ching Lee

TL;DR: T1 isolated from Gastrodia elata is a promising candidate in developing pharmacological and cosmetic agents of great potency in skin-whitening and the molecular modeling demonstrates that the sulfur atom of T1 coordinating with the copper ions in the active site of tyrosinase is essential for mushroom tyrosine inhibition and the ability of diminishing the human melanin synthesis.

TL;DR: This study provides an insight into the structural and functional roles of key amino acids of tripeptides derived from the natural compound B16, and the results are expected to be useful for the development of tyrosinase inhibitors.

TL;DR: MPT0L145 is a first-in-class PIK3C3/FGFR inhibitor, providing an innovative strategy to design new compounds that increase autophagy, but simultaneously perturb its process to promote bladder cancer cell death.

TL;DR: It is found that lanatoside C, an anti-arrhythmic agent extracted from Digitalis lanata, inhibited the growth of HCC cells and dramatically decreased tumor volume as well as delayed tumor growth without obvious body weight loss, the first demonstration that the anticancer effects of lanatosides C are mainly attributable to PKCδ activation.

TL;DR: The functional role of Cysteine residue positional preference and the selectivity of specific amino acids in cysteine-containing dipeptides against tyrosinase is revealed, aiding in developing skin-whitening products.