Yuan Li

TL;DR: It is demonstrated that the inactivation of Gi proteins by intraperitoneal injection of pertussis toxin into 2-week-old prehypertensive SHR prevented the development of hypertension up to 4 weeks and that, thereafter, it started to increase and reached the same level found in untreated SHR after 6 weeks.

TL;DR: Ex vivo vasoactive peptides, through increased oxidative stress and resultant activation of c-Src, transactivate EGF-R, which through mitogen-activated protein (MAP) kinase signaling may contribute to the hyperproliferation of VSMC from SHR.

TL;DR: In this paper, the authors investigated whether in vivo treatment of spontaneously hypertensive rats (SHRs) with C-ANP 4-23 could attenuate the development of high blood pressure (BP) and explored the underlying mechanisms responsible for this response.

TL;DR: C-ANP and small peptide fragments containing 12 amino acids inhibit proliferative responses of vasoactive peptides through G(i)alpha protein and MAP kinase/phosphatidylinositol 3-kinase/AKT pathways.

TL;DR: In this article, the axon arborization of substantia nigra pars compacta (SNc) DA neurons was found to be a key determinant of axonal vulnerability to 6-OHDA lesion.