中枢神経系疾患の治療は正常細胞（ニューロン）の機能維持を目的とするが，脳血管障害のように機能障害の原因が細胞の死滅に基づくことは多い．一方，脳腫瘍の治療においては薬物療法や放射線療法といった腫瘍細胞の死滅を目標とするものが大きな位置を占める．いずれの場合にも，細胞死の機序を理解することは各種病態や治療法の理解のうえで重要である．現在のところ最も研究の進んでいる細胞死の型はアポトーシスである．そのなかで重要な位置を占めるミトコンドリアにおける反応および抗アポトーシス因子について概要を紹介する．

Neuroscience 細胞死：最近の知見

Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders--including models of autism spectrum disorder and obsessive compulsive disorder--that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action.

/pdf/neurobiology-of-rodent-self-grooming-and-its-value-for-20dwt1scbg.pdf

Neurobiology of rodent self-grooming and its value for translational neuroscience.

Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders — including models of autism spectrum disorder and obsessive compulsive disorder — that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action.

Neurobiology of rodent self-grooming and its value for translational neuroscience

It is widely thought that phasic and sustained responses to threat reflect dissociable circuits centered on the central nucleus of the amygdala (Ce) and the bed nucleus of the stria terminalis (BST), the two major subdivisions of the central extended amygdala. Early versions of this hypothesis remain highly influential and have been incorporated into the National Institute of Mental Health Research Research Domain Criteria framework. However, new observations encourage a different perspective. Anatomical studies show that the Ce and BST form a tightly interconnected unit, where different kinds of threat-relevant information can be integrated and used to assemble states of fear and anxiety. Imaging studies in humans and monkeys show that the Ce and BST exhibit similar functional profiles. Both regions are sensitive to a range of aversive challenges, including uncertain or temporally remote threat; both covary with concurrent signs and symptoms of fear and anxiety; both show phasic responses to short-lived threat; and both show heightened activity during sustained exposure to diffusely threatening contexts. Mechanistic studies demonstrate that both regions can control the expression of fear and anxiety during sustained exposure to diffuse threat. These observations compel a reconsideration of the central extended amygdala's contributions to fear and anxiety and its role in neuropsychiatric disease.

https://www.jneurosci.org/content/jneuro/36/31/8050.full.pdf

Contributions of the Central Extended Amygdala to Fear and Anxiety.

Objective Gray matter (GM) damage and meningeal inflammation have been associated with early disease onset and a more aggressive disease course in multiple sclerosis (MS), but can these changes be identified in the patient early in the disease course? Methods To identify possible biomarkers linking meningeal inflammation, GM damage, and disease severity, gene and protein expression were analyzed in meninges and cerebrospinal fluid (CSF) from 27 postmortem secondary progressive MS and 14 control cases. Combined cytokine/chemokine CSF profiling and 3T magnetic resonance imaging (MRI) were performed at diagnosis in 2 independent cohorts of MS patients (35 and 38 subjects) and in 26 non-MS patients. Results Increased expression of proinflammatory cytokines (IFNγ, TNF, IL2, and IL22) and molecules related to sustained B-cell activity and lymphoid-neogenesis (CXCL13, CXCL10, LTα, IL6, and IL10) was detected in the meninges and CSF of postmortem MS cases with high levels of meningeal inflammation and GM demyelination. Similar proinflammatory patterns, including increased levels of CXCL13, TNF, IFNγ, CXCL12, IL6, IL8, and IL10, together with high levels of BAFF, APRIL, LIGHT, TWEAK, sTNFR1, sCD163, MMP2, and pentraxin III, were detected in the CSF of MS patients with higher levels of GM damage at diagnosis. Interpretation A common pattern of intrathecal (meninges and CSF) inflammatory profile strongly correlates with increased cortical pathology, both at the time of diagnosis and at death. These results suggest a role for detailed CSF analysis combined with MRI as a prognostic marker for more aggressive MS. Ann Neurol 2018 Ann Neurol 2018;83:739-755.

/pdf/inflammatory-intrathecal-profiles-and-cortical-damage-in-opyffnjpnz.pdf

Inflammatory intrathecal profiles and cortical damage in multiple sclerosis

Inactivation of the bed nucleus of the stria terminalis suppresses the innate fear responses of rats induced by the odor of cat urine.

Soluble cd146 in cerebrospinal fluid of active multiple sclerosis

In this work, we propose a new type of multispectral imaging system, named multispectral curved compound eye camera (MCCEC). The so called MCCEC consists of three subsystems, a curved micro-lens array integrated with selected narrow-band optical filters, an optical transformation subsystem, and the data processing unit with an image sensor. The novel MCCEC system can achieve multi-spectral imaging at an ultra-large field of view (FOV), and obtain information of multiple spectrum segments at real time. Moreover, the system has the advantages of small size, light weight, and high sensitivity in comparison with conventional multispectral cameras. In current work, we mainly focus on the optical design of the MCCEC based on the overlap of FOV between the neighboring clusters of ommatidia to achieve the multispectral imaging at an ultra-large FOV. The optical layout of the curved micro-lens array, narrow-band filter array and the optical relay system for image plane transformation are carefully designed and optimized. The whole size of the optical system is 93 mm × 42 mm × 42 mm. The simulation results show that a maximum FOV of about 120° can be achieved for seven-waveband multispectral imaging with center wavelengths of 480 nm, 550 nm, 591 nm, 676 nm, 704 nm, 740 nm, and 767 nm. The new designed MCCEC has a great potential as an airborne or satellite-born payload for real time remote sensing and thus paves a new way for the design of compact and light-weight spectral-imaging cameras with an ultra large FOV.

Multispectral curved compound eye camera.

The dependence of angular distributions of fast electrons generated in the interaction of p-polarized femtosecond laser pulses with foil targets on laser intensities is investigated. A novel fast electron beam along the front target surface is observed for high laser intensity. It is found that the electron acceleration along the target surface is more efficient than those in other directions.

Effective fast electron acceleration along the target surface

In this Letter, we demonstrate the design and fabrication of a biomimetic curved compound-eye camera (BCCEC) with a high resolution for detecting distant moving objects purpose. In contrast to previously reported compound-eye cameras, our BCCEC has two distinct features. One is that the ommatidia of the compound eye are deployed on a curved surface which makes a large field of view (FOV) possible. The other is that each ommatidium has a relatively large optical entrance and long focal length so that a distant object can be imaged. To overcome the mismatch between the curved focal plane formed by the curved compound eye and the planar focal plane of the CMOS image sensor (CIS), an optical relay subsystem is introduced between the compound eye and the CIS. As a result, a BCCEC with 127 ommatidia in the compound eye is designed and fabricated to achieve a large FOV of up to 98∘×98∘. The experimental results show that objects with a size of 100 mm can be clearly resolved at a distance of 25 m. The capture of the motion trajectories of a moving object is also demonstrated, which makes it possible to detect and track the moving targets in a huge FOV for security surveillance purposes.

Yuanjie Zhang

Papers

Inactivation of the bed nucleus of the stria terminalis suppresses the innate fear responses of rats induced by the odor of cat urine.

Soluble cd146 in cerebrospinal fluid of active multiple sclerosis

Multispectral curved compound eye camera.

Effective fast electron acceleration along the target surface

Biomimetic curved compound-eye camera with a high resolution for the detection of distant moving objects.