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Yuechen Han
Researcher at Shandong University
Publications - 67
Citations - 870
Yuechen Han is an academic researcher from Shandong University. The author has contributed to research in topics: Facial nerve & Spiral ganglion. The author has an hindex of 13, co-authored 60 publications receiving 611 citations.
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Journal ArticleDOI
Wnt Signaling Activates TP53-Induced Glycolysis and Apoptosis Regulator and Protects Against Cisplatin-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea
Wenwen Liu,Xiaochen Xu,Zhaomin Fan,Gaoying Sun,Yuechen Han,Daogong Zhang,Lei Xu,Mingming Wang,Xue Wang,Shasha Zhang,Mingliang Tang,Jianfeng Li,Renjie Chai,Haibo Wang +13 more
TL;DR: This study is the first to indicate that Wnt signaling activates TIGAR and protects SGNs against cisplatin-induced damage through the inhibition of oxidative stress and apoptosis in S GNs, and this might offer novel therapeutic targets for the prevention of SGN injury.
Journal ArticleDOI
PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.
Wenwen Liu,Lei Xu,Xue Wang,Daogong Zhang,Gaoying Sun,Man Wang,Mingming Wang,Yuechen Han,Renjie Chai,Haibo Wang +9 more
TL;DR: In this article, the effect of autophagy on cisplatin-induced SGN injury is investigated, and it was shown that autophagic flux was activated in SGNs after cisplatal damage, whereas these were exacerbated by the autophag inhibitor 3-methyladenine.
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Meclofenamic Acid Reduces Reactive Oxygen Species Accumulation and Apoptosis, Inhibits Excessive Autophagy, and Protects Hair Cell-Like HEI-OC1 Cells From Cisplatin-Induced Damage.
He Li,Yongdong Song,Zuhong He,Xiaoyun Chen,Xianmin Wu,Xianmin Wu,Xiaofei Li,Xiaohui Bai,Wenwen Liu,Boqin Li,Shanshan Wang,Yuechen Han,Lei Xu,Daogong Zhang,Jianfeng Li,Renjie Chai,Haibo Wang,Zhaomin Fan +17 more
TL;DR: The findings show that MA2 has a protective effect and improves the viability of HEI-OC1 cells after cisplatin treatment, and they provide new insights into potential therapeutic targets for the amelioration of cis platin-induced ototoxicity.
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The Three-Dimensional Culture System with Matrigel and Neurotrophic Factors Preserves the Structure and Function of Spiral Ganglion Neuron In Vitro
Gaoying Sun,Wenwen Liu,Zhaomin Fan,Daogong Zhang,Yuechen Han,Lei Xu,Jieyu Qi,Shasha Zhang,Bradley T Gao,Xiaohui Bai,Jianfeng Li,Renjie Chai,Haibo Wang +12 more
TL;DR: 3D culture system preserves the structure and function of SGN in explant culture and combined with neurotrophic factors had accumulated effects in promoting the neurites outgrowth compared with 3D culture or NFs treatment only groups.
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c-Myb knockdown increases the neomycin-induced damage to hair-cell-like HEI-OC1 cells in vitro.
Xiaoyu Yu,Wenwen Liu,Zhaomin Fan,Fuping Qian,Daogong Zhang,Yuechen Han,Lei Xu,Gaoying Sun,Jieyu Qi,Jieyu Qi,Shasha Zhang,Shasha Zhang,Mingliang Tang,Mingliang Tang,Jianfeng Li,Renjie Chai,Renjie Chai,Haibo Wang +17 more
TL;DR: Evidence is provided that c-Myb might serve as a new target for the prevention of aminoglycoside-induced HC loss by knocking down c- myb expression with shRNA transfection in HEI-OC1 cells and finding that c -Myb knockdown decreased cell viability, increased expression of pro-apoptotic factors, and enhanced cell apoptosis after neomycin insult.