Jianfeng Li

TL;DR: This study is the first to indicate that Wnt signaling activates TIGAR and protects SGNs against cisplatin-induced damage through the inhibition of oxidative stress and apoptosis in S GNs, and this might offer novel therapeutic targets for the prevention of SGN injury.

TL;DR: Long-term deficiency of dietary fiber intake increases the susceptibility to AAD, whereas proper fiber supplementation promotes effectively the balance of Th1/Th2 immunity and then attenuates allergic inflammatory responses significantly, as well as optimizes the structure of intestinal microbiota, which suggests potential for novel preventive and therapeutic intervention.

TL;DR: The findings show that MA2 has a protective effect and improves the viability of HEI-OC1 cells after cisplatin treatment, and they provide new insights into potential therapeutic targets for the amelioration of cis platin-induced ototoxicity.

TL;DR: It is demonstrated that mTORC1 signaling is highly and specifically activated in the cochlear neurosensory epithelium (NSE) in aging mice, and rapamycin injection prevents ARHL, and it is suggested that reduction of m TORC1 activity in co chlear hair cells may be a potential strategy to prevent ARHL.

TL;DR: 3D culture system preserves the structure and function of SGN in explant culture and combined with neurotrophic factors had accumulated effects in promoting the neurites outgrowth compared with 3D culture or NFs treatment only groups.