Zhaomin Fan

TL;DR: This study is the first to indicate that Wnt signaling activates TIGAR and protects SGNs against cisplatin-induced damage through the inhibition of oxidative stress and apoptosis in S GNs, and this might offer novel therapeutic targets for the prevention of SGN injury.

TL;DR: The findings show that MA2 has a protective effect and improves the viability of HEI-OC1 cells after cisplatin treatment, and they provide new insights into potential therapeutic targets for the amelioration of cis platin-induced ototoxicity.

TL;DR: 3D culture system preserves the structure and function of SGN in explant culture and combined with neurotrophic factors had accumulated effects in promoting the neurites outgrowth compared with 3D culture or NFs treatment only groups.

TL;DR: Evidence is provided that c-Myb might serve as a new target for the prevention of aminoglycoside-induced HC loss by knocking down c- myb expression with shRNA transfection in HEI-OC1 cells and finding that c -Myb knockdown decreased cell viability, increased expression of pro-apoptotic factors, and enhanced cell apoptosis after neomycin insult.

TL;DR: It is found that the three-dimensional (3D)-matrigel culture environment significantly suppressed apoptosis and improved SGN survival in vitro, which enabled the long-term culture of SGNs for up to 6 months and helped to maintain and promote the electrophysiological properties of the S GNs.