Y
Yuichi Tokuda
Researcher at Kyoto Prefectural University of Medicine
Publications - 20
Citations - 393
Yuichi Tokuda is an academic researcher from Kyoto Prefectural University of Medicine. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 6, co-authored 15 publications receiving 318 citations.
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Journal ArticleDOI
Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population
Masakazu Nakano,Yoko Ikeda,Takazumi Taniguchi,Tomohito Yagi,Masahiro Fuwa,Natsue Omi,Yuichi Tokuda,Masami Tanaka,Kengo Yoshii,Masaaki Kageyama,Shigeta Naruse,Akira Matsuda,Kazuhiko Mori,Shigeru Kinoshita,Kei Tashiro +14 more
TL;DR: It turned out that 3 genetic loci probably associated with POAG have been identified, and these findings would provide the foundation for future studies to build on, such as for the metaanalysis, to reveal the molecular mechanism of the POAG pathogenesis.
Journal ArticleDOI
Common Variants in CDKN2B-AS1 Associated with Optic-Nerve Vulnerability of Glaucoma Identified by Genome-Wide Association Studies in Japanese
Masakazu Nakano,Yoko Ikeda,Yuichi Tokuda,Masahiro Fuwa,Masahiro Fuwa,Natsue Omi,Morio Ueno,Kojiro Imai,Hiroko Adachi,Masaaki Kageyama,Kazuhiko Mori,Shigeru Kinoshita,Kei Tashiro +12 more
TL;DR: POAG-associated variants in the CDKN2B-AS1 locus are identified using a Japanese population and could be associated specifically with the vulnerability of the optic nerve to IOP, which is useful for investigating the etiology of glaucoma.
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Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by means of a genome-wide association study.
Mayumi Ueta,Chie Sotozono,Masakazu Nakano,Takazumi Taniguchi,Tomohito Yagi,Yuichi Tokuda,Masahiro Fuwa,Tsutomu Inatomi,Norihiko Yokoi,Kei Tashiro,Shigeru Kinoshita +10 more
TL;DR: It is demonstrated, using both genetic and functional analyses, that EP3 could be a key player in the pathogenesis of SJS/TEN accompanied by ocular complications.
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Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population
Masakazu Nakano,Yoko Ikeda,Yuichi Tokuda,Masahiro Fuwa,Morio Ueno,Kojiro Imai,Ryuichi Sato,Natsue Omi,Hiroko Adachi,Masaaki Kageyama,Kazuhiko Mori,Shigeru Kinoshita,Kei Tashiro +12 more
TL;DR: The results suggested that the combination of newly discovered variants in these genes might be useful for precise XFG risk assessment, as well as for elucidating the molecular mechanism of XFG pathogenesis through XFS.
Journal ArticleDOI
Metabolites Interrogation in Cell Fate Decision of Cultured Human Corneal Endothelial Cells.
Junji Hamuro,Kohsaku Numa,Tomoko Fujita,Munetoyo Toda,Koji Ueda,Yuichi Tokuda,Atushi Mukai,Masakazu Nakano,Morio Ueno,Shigeru Kinoshita,Chie Sotozono +10 more
TL;DR: The findings suggest that the cell fate decision of cHCECs may be dictated at least partly through metabolic rewiring, linking upregulated glycolytic enzymes and influx of glutamine to the tricarboxylic acid cycle.