Koji Ueda

TL;DR: A simple anti-CD9 antibody-coupled highly porous monolithic silica microtips are constructed which allowed automated rapid and reproducible exosome extraction from multiple clinical samples and can promote not only biomarker discovery studies but also wide range of omics researches about exosomes.

TL;DR: It is shown that SETD8 regulates the function of proliferating cell nuclear antigen (PCNA) protein through lysine methylation, and an increase of methylated PCNA was found in cancer cells, and the expression levels ofSETD8 and PCNA were correlated in cancer tissue samples, suggesting that aberrant lysines methylation of PCNA may play a role in human carcinogenesis.

TL;DR: It is demonstrated that exosomes isolated by size-exclusion chromatography from a highly metastatic human oral cancer cell line, HOC313-LM, induced cell growth through the activation of ERK and AKT as well as promoted cell motility of the poorly metastaticcancer cell line HOC 313-P.

TL;DR: A high-throughput screening of a compound library followed by structure-activity relationship studies, and successfully obtained a highly potent MELK inhibitor OTSSP167 with IC50 of 0.41 nM, which should be a promising compound possibly to suppress the growth of tumor-initiating cells and be applied for treatment of a wide range of human cancer.

TL;DR: In vivo and in vitro citrullination of the arginine 3 residue of histone H4 (cit-H4R3) in response to DNA damage through the p53-PADI4 pathway is shown and reveals that cit-H 4R3 may be an 'apoptotic histone code' to detect damaged cells and induce nuclear fragmentation, which has a crucial role in carcinogenesis.