N
Natsue Omi
Researcher at Kyoto Prefectural University of Medicine
Publications - 9
Citations - 346
Natsue Omi is an academic researcher from Kyoto Prefectural University of Medicine. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 6, co-authored 8 publications receiving 317 citations.
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Journal ArticleDOI
Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population
Masakazu Nakano,Yoko Ikeda,Takazumi Taniguchi,Tomohito Yagi,Masahiro Fuwa,Natsue Omi,Yuichi Tokuda,Masami Tanaka,Kengo Yoshii,Masaaki Kageyama,Shigeta Naruse,Akira Matsuda,Kazuhiko Mori,Shigeru Kinoshita,Kei Tashiro +14 more
TL;DR: It turned out that 3 genetic loci probably associated with POAG have been identified, and these findings would provide the foundation for future studies to build on, such as for the metaanalysis, to reveal the molecular mechanism of the POAG pathogenesis.
Journal ArticleDOI
Common Variants in CDKN2B-AS1 Associated with Optic-Nerve Vulnerability of Glaucoma Identified by Genome-Wide Association Studies in Japanese
Masakazu Nakano,Yoko Ikeda,Yuichi Tokuda,Masahiro Fuwa,Masahiro Fuwa,Natsue Omi,Morio Ueno,Kojiro Imai,Hiroko Adachi,Masaaki Kageyama,Kazuhiko Mori,Shigeru Kinoshita,Kei Tashiro +12 more
TL;DR: POAG-associated variants in the CDKN2B-AS1 locus are identified using a Japanese population and could be associated specifically with the vulnerability of the optic nerve to IOP, which is useful for investigating the etiology of glaucoma.
Journal Article
LOXL1 genetic polymorphisms are associated with exfoliation glaucoma in the Japanese population
Kazuhiko Mori,Kojiro Imai,Akira Matsuda,Yoko Ikeda,Shigeta Naruse,Hisako Hitora-Takeshita,Masakazu Nakano,Takazumi Taniguchi,Natsue Omi,Kei Tashiro,Shigeru Kinoshita +10 more
TL;DR: Although the functional effects of the LOXL1 SNP appear to be qualitative rather than quantitative, the amino acid substitution (R141L) caused by SNP rs1048661 is not a simple decisive factor for XFG due to the inverted allele frequency between Japanese XFG and Caucasian XFG patients.
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Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population
Masakazu Nakano,Yoko Ikeda,Yuichi Tokuda,Masahiro Fuwa,Morio Ueno,Kojiro Imai,Ryuichi Sato,Natsue Omi,Hiroko Adachi,Masaaki Kageyama,Kazuhiko Mori,Shigeru Kinoshita,Kei Tashiro +12 more
TL;DR: The results suggested that the combination of newly discovered variants in these genes might be useful for precise XFG risk assessment, as well as for elucidating the molecular mechanism of XFG pathogenesis through XFS.
Journal ArticleDOI
Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice.
Masaya Ikegawa,Hua Han,Akihiko Okamoto,Ryosuke Matsui,Masami Tanaka,Natsue Omi,Mahito Miyamae,Junya Toguchida,Kei Tashiro +8 more
TL;DR: The results suggest that the Sfrp2 deleted mice can be a useful animal model to study human syndactyly/preaxial synpolydactYly defects.