Y
Yuji Saito
Researcher at Tokyo Institute of Technology
Publications - 94
Citations - 2548
Yuji Saito is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Lipase & Platelet. The author has an hindex of 29, co-authored 94 publications receiving 2488 citations. Previous affiliations of Yuji Saito include Kyoto University.
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Application of polyethylene glycol-modified enzymes in biotechnological processes: organic solvent-soluble enzymes
TL;DR: Modified hydrolytic enzymes catalysed the reverse reaction of hydrolysis in organic solvents: formation of acid—amide bonds by modified chymotrypsin, and ester synthesis and esters exchange reactions by modified lipase.
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A novel function of tissue-type transglutaminase: protein disulphide isomerase.
Go Hasegawa,Motoi Suwa,Yasuo Ichikawa,Tetsuro Ohtsuka,Satoru Kumagai,Masashi Kikuchi,Yoshitaka Sato,Yuji Saito +7 more
TL;DR: It is found that tissue-type transglutaminase (tTG), also called TGc, TGase2 and Galpha(h), has the activity of protein disulphide isomerase (PDI), and it is shown that tTG converts completely reduced/denatured inactive RNase A molecule to the native active enzyme.
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Ester synthesis catalyzed by polyethylene glycol-modified lipase in benzene
Yuji Inada,Hiroyuki Nishimura,Katsunobu Takahashi,Takayuki Yoshimoto,Anutosh Ranjan Saha,Yuji Saito +5 more
TL;DR: The modified lipase was modified with 2,4-bis(o-methoxy-polyethylene glycol)-6-chloro-s-triazine(activated PEG2) to catalyze ester synthesis reaction in benzene and was soluble in organic solvents such as benzene, toluene, chloroform and dioxane.
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12S-hydroxyeicosatetraenoic acid plays a central role in the regulation of platelet activation.
Fujio Sekiya,Junichi Takagi,Tomoko Usui,Keiko Kawajiri,Yuichi Kobayashi,Fumie Sato,Yuji Saito +6 more
TL;DR: It is shown that 12-HETE enhances thrombin-induced aggregation of bovine platelets, in sharp contrast with the case of collagen, and is able to prevent the prostaglandin E1-induced elevation of platelet cAMP level and counteracts its inhibitory effect on platelet aggregations.
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Engineering physicochemical and biological properties of proteins by chemical modification
TL;DR: Proteins can be modified by chemically binding synthetic or natural macromolecules to the surface of the molecules to counter some of the drawbacks of the native proteins and improves properties which could be important in their use as protein drugs and/or catalysts in bioreactors.