Y
Yukai He
Researcher at Georgia Regents University
Publications - 59
Citations - 3583
Yukai He is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Immune system & Cytotoxic T cell. The author has an hindex of 27, co-authored 53 publications receiving 3147 citations. Previous affiliations of Yukai He include German Cancer Research Center & University of Pittsburgh.
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Journal ArticleDOI
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo.
Jennifer R. Grandis,Stephanie D. Drenning,Qing Zeng,Simon C. Watkins,Mona F. Melhem,Sohei Endo,Daniel Johnson,Leaf Huang,Yukai He,Jae D. Kim +9 more
TL;DR: Analysis of the expression and constitutive activation of Stat3 in tumors and normal mucosa from patients with head and neck cancer provides evidence that constitutively activated Stat3 is an early event in head and head carcinogenesis that contributes to the loss of growth control by an anti-apoptotic mechanism.
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Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes.
Madhav D. Sharma,De Yan Hou,Yanjun Liu,Pandelakis A. Koni,Richard Metz,Phillip Chandler,Andrew L. Mellor,Yukai He,David H. Munn +8 more
TL;DR: Tregs in TDLNs can be actively reprogrammed in situ into T-helper cells, without the need for physical depletion, and IDO serves as a key regulator of this critical conversion.
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Oncolytic viruses as therapeutic cancer vaccines
David L. Bartlett,Zuqiang Liu,Magesh Sathaiah,Roshni Ravindranathan,Zongbi Guo,Yukai He,Zong Sheng Guo +6 more
TL;DR: In summary, OVs properly armed or in rational combinations are potent therapeutic cancer vaccines.
Journal ArticleDOI
Skin-derived dendritic cells induce potent CD8(+) T cell immunity in recombinant lentivector-mediated genetic immunization.
TL;DR: It is shown that cutaneous delivery of lentivirus results in direct transfection of sDCs and potent and prolonged antigen presentation and it is suggested that antigen presentation by s DCs contributes to the high potency of lentivector-mediated genetic immunization.
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Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics
Zong Sheng Guo,Binfeng Lu,Zongbi Guo,Esther Giehl,Mathilde Feist,Enyong Dai,Weilin Liu,Walter J. Storkus,Yukai He,Zuqiang Liu,David L. Bartlett +10 more
TL;DR: The current understanding of virus biology and viral genes involved in host-virus interactions to further improve the utility of these agents in therapeutic applications is summarized and some perspectives regarding the development of next generation VV vectors for use as cancer therapeutics are offered.