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David H. Munn
Researcher at Georgia Regents University
Publications - 255
Citations - 35440
David H. Munn is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 83, co-authored 246 publications receiving 31855 citations. Previous affiliations of David H. Munn include Hokkaido University & University of Nebraska Medical Center.
Papers
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Journal ArticleDOI
Prevention of allogeneic fetal rejection by tryptophan catabolism
David H. Munn,Min Zhou,John T. Attwood,Igor Bondarev,Simon J. Conway,Brendan Marshall,Corrie C. Brown,Andrew L. Mellor +7 more
TL;DR: In 1953 Medawar pointed out that survival of the genetically disparate (allogeneic) mammalian conceptus contradicts the laws of tissue transplantation and suppresses T cell activity and defends itself against rejection.
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IDO expression by dendritic cells: tolerance and tryptophan catabolism.
Andrew L. Mellor,David H. Munn +1 more
TL;DR: This review summarizes key recent developments and proposes a unifying model for the role of IDO in tolerance induction, including studies of mammalian pregnancy, tumour resistance, chronic infections and autoimmune diseases.
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Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis
Nagendra Singh,Ashish Gurav,Sathish Sivaprakasam,Evan Brady,Ravi Padia,Huidong Shi,Muthusamy Thangaraju,Puttur D. Prasad,Santhakumar Manicassamy,David H. Munn,Jeffrey R. Lee,Stefan Offermanns,Vadivel Ganapathy +12 more
TL;DR: This paper showed that GPR109a signaling promoted anti-inflammatory properties in colonic macrophages and dendritic cells and enabled them to induce differentiation of Treg cells and IL-10-producing T cells.
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Inhibition of t cell proliferation by macrophage tryptophan catabolism
David H. Munn,Ebrahim Shafizadeh,John T. Attwood,Igor Bondarev,Achal Pashine,Andrew L. Mellor +5 more
TL;DR: It is shown that monocytes that have differentiated under the influence of macrophage colony-stimulating factor acquire the ability to suppress T cell proliferation in vitro via rapid and selective degradation of tryptophan by IDO.
Journal ArticleDOI
GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.
David H. Munn,Madhav D. Sharma,Babak Baban,Heather P. Harding,Yuhong Zhang,David Ron,Andrew L. Mellor +6 more
TL;DR: It is shown that IDO-expressing plasmacytoid DCs activate the GCN2 kinase pathway in responding T cells, allowing them to detect and respond to conditions created by IDO.