Y
Yuki Saito
Researcher at University of Tsukuba
Publications - 15
Citations - 421
Yuki Saito is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Orexin & Non-rapid eye movement sleep. The author has an hindex of 8, co-authored 12 publications receiving 335 citations. Previous affiliations of Yuki Saito include Kanazawa University.
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Journal Article
Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis.
Takashi Matsushita,Minoru Hasegawa,Manabu Fujimoto,Yasuhito Hamaguchi,Kazuhiro Komura,Takashi Hirano,Mayuka Horikawa,Miki Kondo,Hidemitsu Orito,Kenzo Kaji,Yuki Saito,Yukiyo Matsushita,Shigeru Kawara,Masahide Yasui,Mariko Seishima,Shoichi Ozaki,Masataka Kuwana,Fumihide Ogawa,Shinichi Sato,Kazuhiko Takehara +19 more
TL;DR: DM patients with anti-ARS antibodies appear to have a more persistent disease course that requires additional therapy compared to those without anti- ARs, and are found in a subset with ILD.
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The loss of MCP-1 attenuates cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer.
Yuki Saito,Minoru Hasegawa,Manabu Fujimoto,Takashi Matsushita,Mayuka Horikawa,Motoi Takenaka,Fumihide Ogawa,Junko Sugama,Douglas A. Steeber,Shinichi Sato,Kazuhiko Takehara +10 more
TL;DR: Findings indicate that MCP-1 may be a critical factor for macrophage recruitment and subsequent skin inflammation and injury during IR cycles, and played a role in apoptosis and injury via inducing iNOS during the reperfusion rather than the ischemic period.
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GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons.
Yuki Saito,Natsuko Tsujino,Emi Hasegawa,Kaori Akashi,Manabu Abe,Michihiro Mieda,Kenji Sakimura,Takeshi Sakurai +7 more
TL;DR: It is confirmed that specific pharmacogenetic stimulation of GABAergic neurons in the POA leads to an increase in the amount of non-rapid eye movement (NREM) sleep, and direct connectivity between POA GABAergic neuron and orexin neurons is examined.
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Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice
TL;DR: Results suggest that an orexin-mediated suppression of REM sleep via potential activation of OX1Rs in the locus coeruleus may possibly contribute to the differential effects on sleep/wakefulness exerted by a DORA as compared to a 2-SORA.
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Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons.
Yuki Saito,Takashi Maejima,Mitsuhiro Nishitani,Emi Hasegawa,Emi Hasegawa,Yuchio Yanagawa,Michihiro Mieda,Takeshi Sakurai +7 more
TL;DR: Electrophysiological experiments found that GABAergic neurons in the VLPO (GABAVLPO neurons) that make direct input to orexin or histaminergic neurons are potently inhibited by noradrenaline and serotonin, suggesting that these monoamines disinhibit histamine and Orexin neurons.