T
Takashi Maejima
Researcher at Kanazawa University
Publications - 52
Citations - 4505
Takashi Maejima is an academic researcher from Kanazawa University. The author has contributed to research in topics: Neurotransmission & Postsynaptic potential. The author has an hindex of 27, co-authored 47 publications receiving 4077 citations. Previous affiliations of Takashi Maejima include Ruhr University Bochum & Brigham and Women's Hospital.
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Journal ArticleDOI
Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals.
TL;DR: The results reveal that endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals to cause the reduction of transmitter release.
Journal ArticleDOI
Presynaptic Inhibition Caused by Retrograde Signal from Metabotropic Glutamate to Cannabinoid Receptors
TL;DR: A signaling mechanism whereby activation of postsynaptic mGluR retrogradely influences presynaptic functions via endocannabinoid system is highlighted, which can be initiated by two distinct stimuli.
Journal ArticleDOI
The CB1 Cannabinoid Receptor Is the Major Cannabinoid Receptor at Excitatory Presynaptic Sites in the Hippocampus and Cerebellum
Yoshinobu Kawamura,Masahiro Fukaya,Takashi Maejima,Takayuki Yoshida,Eriko Miura,Masahiko Watanabe,Takako Ohno-Shosaku,Masanobu Kano +7 more
TL;DR: Electrophysiological and immunohistochemical data and morphological data indicate that CB1 is responsible for cannabinoid-dependent suppression of excitatory transmission in the hippocampus and cerebellum.
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Phospholipase Cβ Serves as a Coincidence Detector through Its Ca2+ Dependency for Triggering Retrograde Endocannabinoid Signal
Yuki Hashimotodani,Takako Ohno-Shosaku,Hiroshi Tsubokawa,Hidenori Ogata,Ken Emoto,Takashi Maejima,Kenji Araishi,Hee-Sup Shin,Masanobu Kano +8 more
TL;DR: PLCbeta1 serves as a coincidence detector through its Ca(2+) dependency for endocannabinoid release in hippocampal neurons and is detected by phospholipase Cbeta1 in hippocampusal neurons.
Journal ArticleDOI
Synaptically Driven Endocannabinoid Release Requires Ca2+-Assisted Metabotropic Glutamate Receptor Subtype 1 to Phospholipase C β4 Signaling Cascade in the Cerebellum
Takashi Maejima,Saori Oka,Yuki Hashimotodani,Takako Ohno-Shosaku,Atsu Aiba,Dianqing Wu,Keizo Waku,Takayuki Sugiura,Masanobu Kano +8 more
TL;DR: The results strongly suggest that under physiological conditions, excitatory synaptic inputs to PCs activate the Ca2+-assisted mGluR1-PLCβ4 cascade, and thereby produce 2-AG, which retrogradely modulates synaptic transmission to PCs.