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Yukiko Nakata
Researcher at National Defense Medical College
Publications - 4
Citations - 187
Yukiko Nakata is an academic researcher from National Defense Medical College. The author has contributed to research in topics: Promyelocytic leukemia protein & Retinoic acid receptor alpha. The author has an hindex of 3, co-authored 4 publications receiving 186 citations.
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Journal Article
Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid
Takashi Ikeda,Yukiko Nakata,Fumihiko Kimura,Ken Sato,Kenneth C. Anderson,Kazuo Motoyoshi,Michael B. Sporn,Donald Kufe +7 more
TL;DR: It is demonstrated that CDDO-Im disrupts intracellular redox balance and thereby activates the extrinsic caspase-8-dependent apoptotic pathway and that MM cells are more sensitive to this agent than normal bone marrow mononuclear cells.
Journal ArticleDOI
Cloning and Characterization of a Novel RING-B-box-Coiled-coil Protein with Apoptotic Function
Fumihiko Kimura,Shinya Suzu,Yukitsugu Nakamura,Yukiko Nakata,Muneo Yamada,Naruo Kuwada,Takuya Matsumura,Takuya Yamashita,Takashi Ikeda,Ken Sato,Kazuo Motoyoshi +10 more
TL;DR: It is found that the RING finger and coiled-coil domains were required for MAIR activity by analysis with deletion mutants, and the addition of zinc to transfectants containing MAIR cDNA as part of a heavy metal-inducible vector caused apoptosis of the cells characterized by cell fragmentation.
Journal ArticleDOI
Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells.
Takashi Ikeda,Fumihiko Kimura,Yukiko Nakata,Ken Sato,K Ogura,Kazuo Motoyoshi,Michael B. Sporn,Donald Kufe +7 more
TL;DR: Results show that CDDO-Im selectively downregulates expression of the PML/retinoic receptor alpha fusion protein by a caspase-dependent mechanism and sensitizes APL cells to the differentiating effects of all-trans retinoic acid (ATRA).