Fumihiko Kimura

TL;DR: The results suggested that the systemic tissue damage seen in most patients with LGL leukemia and NK–type lymphoma is due to sFasL produced by these malignant cells, and neutralizing anti–FAsL antibodies or matrix metalloproteinase inhibitors may be of use in modulating such tissue damage.

TL;DR: The findings indicate that macrophage phenotype and function are differentially regulated even at the level of the single receptor, Fms, the receptor tyrosine kinase.

TL;DR: Results indicate that the prognosis of AML could be stratified by the major mutation status in combination with cytogenetics, and that AML patients could be clearly stratified into five risk groups for overall survival by including the mutation status of DNMT3A, MLL-PTD and TP53 genes in the risk classification system of the European LeukemiaNet.

TL;DR: It is demonstrated that CDDO-Im disrupts intracellular redox balance and thereby activates the extrinsic caspase-8-dependent apoptotic pathway and that MM cells are more sensitive to this agent than normal bone marrow mononuclear cells.

TL;DR: It is indicated that major and minor AB0 incompatibility have specific effects on transplant-related mortality and acute graft-versus-host disease in recipients of bone marrow transplants from unrelated donors.