Yukio Aso

TL;DR: The purpose of this article is to review literature describing the effect of molecular mobility on chemical stability during storage of amorphous pharmaceuticals, and to seek a better understanding of the relative significance of molecular Mobility and other factors for chemical reactivity.

TL;DR: The inhibition of crystallization of amorphous acetaminophen by polyvinylpyrrolidone and polyacrylic acid and the findings suggest that the stronger stabilizing effect of PAA is due to the stronger interaction with ACTA.

TL;DR: The overall crystallization rates and mean relaxation times of amorphous nifedipine and phenobarbital in the presence of poly(vinylpyrrolidone) (PVP) were determined at various temperatures to gain further insight into the effect of molecular mobility on the crystallization rate of areorphous drugs and the possibility of predicting stability from their molecular mobility.

TL;DR: The physicochemical properties of progesterone-loaded poly(l-lactide) microspheres prepared by the solvent evaporation method were studied, focusing on the crystallinity of the polymer matrices as discussed by the authors.

TL;DR: In this paper, drug release and matrix degradation of poly (d,l -lactide) microspheres with different glass transition temperatures (T g ) were investigated at various temperatures in order to clarify the effect of temperature on mechanisms of drug release.