Journal ArticleDOI
Preparation of poly(l-lactide) microspheres of different crystalline morphology and effect of crystalline morphology on drug release rate
TLDR
The physicochemical properties of progesterone-loaded poly(l-lactide) microspheres prepared by the solvent evaporation method were studied, focusing on the crystallinity of the polymer matrices as discussed by the authors.About:
This article is published in Journal of Controlled Release.The article was published on 1991-04-01. It has received 127 citations till now. The article focuses on the topics: Crystallinity & Differential scanning calorimetry.read more
Citations
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Journal ArticleDOI
Polymer microspheres for controlled drug release
S. Freiberg,X. X. Zhu +1 more
TL;DR: This review presents the methods used in the preparation of microspheres from monomers or from linear polymers and discusses the physio-chemical properties that affect the formation, structure, and morphology of the spheres.
Journal ArticleDOI
Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology.
TL;DR: The findings will be outlined according to the four major substeps of microsphere preparation by solvent extraction/evaporation, namely, incorporation of the bioactive compound, formation of the microdroplets, solvent removal and harvesting and drying the particles.
Journal ArticleDOI
Preparation of microspheres by the solvent evaporation technique
TL;DR: The microencapsulation process in which the removal of the hydrophobic polymer solvent is achieved by evaporation has been widely reported in recent years for the preparation of microspheres and microcapsules based on biodegradable polymers and copolymers of hydroxy acids.
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Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles.
TL;DR: Against the backdrop of an increasing number of new, poorly orally available drug entities entering development, microparticle delivery systems may be a viable strategy to rescue an otherwise undeliverable substance.
Journal ArticleDOI
Microencapsulation by solvent evaporation: state of the art for process engineering approaches.
TL;DR: The current state of the art concerning this technique is reviewed by focusing on the influence of the physical properties of materials and operating conditions on the microspheres obtained and the surprising lack of knowledge on certain aspects, such as the mechanism of formation of pores in the micro Spheres and the experimental study on the solidification of microsphere.
References
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Journal ArticleDOI
Characterization of Drug-Loaded Poly(d,l-lactide) Microspheres
TL;DR: Shelf-life stability of lomustine and progesterone was reduced by incorporation in the microspheres, presumably due to their molecular dispersion in the poly(d,l-lactide).
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The Preparation and Evaluation of Drug-Containing Poly( dl -lactide) Microspheres Formed by the Solvent Evaporation Method
TL;DR: The release profile of quinidine from the microspheres was characterized by three different release phases, a lag time with no drug release, a burst effect of rapid drug release within a short period of time, and a slow release phase, respectively.
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Porous biodegradable microspheres for controlled drug delivery. I. Assessment of processing conditions and solvent removal techniques.
TL;DR: The microspheres remained relatively intact during the in vitro release of methylene blue, confirming that the incorporated agent was confined to the walls of the porous network and collapse of the polymer structure was evident after 7 days.
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Formation and Characterization of Cisplatin Loaded Poly(d,l-Lactide) Microspheres for Chemoembolization
TL;DR: The drug incorporation efficiency was markedly improved after saturation of the dispersing phase with cisplatin, and the amount of drug incorporated increased with increasing mean microsphere diameter.
Journal ArticleDOI
Microencapsulation using poly(L-lactic acid). I: Microcapsule properties affected by the preparative technique
R. Jalil,J. R. Nixon +1 more
TL;DR: The morphology of the microcapsules and the surface properties were found to be affected distinctly by the two techniques and Microcapsules from the o/w system showed a smooth and less porous surface, whereas a highly porous surface containing embedded PB crystals was found in the micro Capsule from the w/o system.