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Yuko Sugimoto
Researcher at Tottori University
Publications - 7
Citations - 399
Yuko Sugimoto is an academic researcher from Tottori University. The author has contributed to research in topics: Chinese hamster ovary cell & Endosome. The author has an hindex of 7, co-authored 7 publications receiving 369 citations.
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Journal ArticleDOI
N-octyl-beta-valienamine up-regulates activity of F213I mutant beta-glucosidase in cultured cells: a potential chemical chaperone therapy for Gaucher disease.
Hou Lin,Yuko Sugimoto,Yuki Ohsaki,Haruaki Ninomiya,Akira Oka,Miyako Taniguchi,Hiroyuki Ida,Yoshikatsu Eto,Seiichiro Ogawa,Yuji Matsuzaki,Miwa Sawa,Takehiko Inoue,Katsumi Higaki,Eiji Nanba,Kousaku Ohno,Yoshiyuki Suzuki +15 more
TL;DR: It is suggested that NOV works as a chemical chaperone to accelerate transport and maturation of F213I mutant β-Glu and may suggest a therapeutic value of this compound for GD.
Journal ArticleDOI
Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann–Pick C1-deficient cells
Yuko Sugimoto,Haruaki Ninomiya,Yuki Ohsaki,Katsumi Higaki,Joanna P. Davies,Yiannis A. Ioannou,Kousaku Ohno +6 more
TL;DR: The results suggest that transport of CT/GM1 complexes from the early endosome to the plasma membrane depends on the function of NPC1, whereas transport to the Golgi apparatus/endoplasmic reticulum does not.
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Endosomal Accumulation of Toll-Like Receptor 4 Causes Constitutive Secretion of Cytokines and Activation of Signal Transducers and Activators of Transcription in Niemann–Pick Disease Type C (NPC) Fibroblasts: A Potential Basis for Glial Cell Activation in the NPC Brain
Michitaka Suzuki,Yuko Sugimoto,Yuki Ohsaki,Makoto Ueno,Shinsuke Kato,Yukisato Kitamura,Hiroshi Hosokawa,Joanna P. Davies,Yiannis A. Ioannou,Marie T. Vanier,Kousaku Ohno,Haruaki Ninomiya +11 more
TL;DR: It is indicated that constitutive cytokine secretion leads to activation of STATs in NPC fibroblasts and that this secretion is partly caused by an endosomal accumulation of TLR4, and that similar signaling events may underlie glial cell activation in the NPC1−/− mouse brain.
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Isolation of NPC1-Deficient Chinese Hamster Ovary Cell Mutants by Gene Trap Mutagenesis
Katsumi Higaki,Haruaki Ninomiya,Yuko Sugimoto,Tatsuya Suzuki,Miyako Taniguchi,Hitoshi Niwa,Peter G. Pentchev,Marie T. Vanier,Kousaku Ohno +8 more
TL;DR: Chinese hamster ovary cell mutants defective in the NPC1 gene (NPC1-trap) will be a useful tool to study the regulation of cellular cholesterol homeostasis and the pathogenesis of Niemann-Pick disease type C.
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Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4
Yuki Ohsaki,Yuko Sugimoto,Michitaka Suzuki,Hiroshi Hosokawa,Tamotsu Yoshimori,Joanna P. Davies,Yiannis A. Ioannou,Marie T. Vanier,Kousaku Ohno,Haruaki Ninomiya +9 more
TL;DR: The results suggest that ubiquitylation of NPC1 and its association with the ESCRT complex are controlled by endosomal cholesterol levels utilizing a mechanism that involves NPC2.