Yumi Ohori-Morita

TL;DR: It is suggested that the shaking-culture method maintains and restores multipotency that is lost following monolayer expansion and thereby shows potential as a promising strategy for regenerative therapies with mesenchymal tissues.

TL;DR: It is suggested that NM-spheroids generated using modified neurosphere culture conditions under continuous shaking recovered their stem cell characteristics in vitro and enhanced bone regeneration in vivo, which should have great clinical potential for bone and tissue regenerative therapies as a stem cell-based biomaterial therapy.

TL;DR: The results reveal the potential regulatory networks between Epfn and the BMP-Smad pathway and suggest that Epfn is a promising target for inducing the differentiation of ameloblasts, which can be used in enamel and tooth regeneration.

TL;DR: In this paper, the involvement of Amelx transcriptional activation in regulating ameloblast differentiation from induced pluripotent stem cells (iPSCs) remains unknown; however, the authors show that Amelox activation at stage 3 significantly enhanced cell adhesion and decreased proliferation and migration.

TL;DR: In this article , a three-dimensional hydrogel-sandwich culture (HGSC) was developed to investigate the effects of mechanical cues on iPSC-derived embryoid bodies (EB) differentiation.