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Yun Xiao
Researcher at Sichuan University
Publications - 31
Citations - 1964
Yun Xiao is an academic researcher from Sichuan University. The author has contributed to research in topics: Tissue engineering & Medicine. The author has an hindex of 17, co-authored 27 publications receiving 1550 citations. Previous affiliations of Yun Xiao include University of Toronto & San Antonio River Authority.
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Journal ArticleDOI
Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes
Sara S. Nunes,Jason W. Miklas,Jie Liu,Roozbeh Aschar-Sobbi,Yun Xiao,Boyang Zhang,Jiahua Jiang,Stéphane Massé,Mark Gagliardi,Anne Hsieh,Nimalan Thavandiran,Michael A. Laflamme,Kumaraswamy Nanthakumar,Gil J. Gross,Peter H. Backx,Peter H. Backx,Gordon Keller,Milica Radisic +17 more
TL;DR: It is demonstrated that the engineered platform allows for the generation of three-dimensional, aligned cardiac tissues (biowires) with frequent striations and that the responses of immature human myocardium to electrical stimulation and pacing are in agreement with cardiomyocyte maturation.
Journal ArticleDOI
In situ mechanical characterization of the cell nucleus by atomic force microscopy.
TL;DR: In this article, a modified atomic force microscopy needle penetration technique is demonstrated to mechanically characterize cell nuclei in situ, based on two different segments on the AFM indentation curves and correlated with simultaneous confocal Z-stack microscopy reconstructions.
In Situ Mechanical Characterization of the Cell Nucleus by Atomic Force
TL;DR: A modified AFM (atomic force microscopy) needle penetration technique is demonstrated to mechanically characterize cell nuclei in situ and shows that there is in situ nucleus softening in the highly metastatic bladder cancer cell line T24 when compared to its less metastatic counterpart RT4.
Journal ArticleDOI
Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle
Yun Xiao,Boyang Zhang,Haijiao Liu,Jason W. Miklas,Mark Gagliardi,Aric Pahnke,Nimalan Thavandiran,Yu Sun,Craig A. Simmons,Gordon Keller,Milica Radisic +10 more
TL;DR: A microfabricated bioreactor is designed to generate 3D micro-tissues, termed biowires, using both primary neonatal rat cardiomyocytes and human embryonic stem cell (hESC) derived carduomyocytes to assess pharmacological effects on cardiac tissue in vitro by perfusion in a cardiac bundle model.
Journal ArticleDOI
Biomaterial based cardiac tissue engineering and its applications
Locke Davenport Huyer,Miles Montgomery,Yimu Zhao,Yun Xiao,Genevieve Conant,Anastasia Korolj,Milica Radisic,Milica Radisic +7 more
TL;DR: Important biomaterial properties for cardiac tissue engineering applications, such as elasticity, degradation, and induced host response, and their relationship to engineered cardiac cell environments are discussed.