J
Jie Liu
Researcher at University of Toronto
Publications - 12
Citations - 1489
Jie Liu is an academic researcher from University of Toronto. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 9, co-authored 12 publications receiving 1226 citations. Previous affiliations of Jie Liu include National Institutes of Health & University Health Network.
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Journal ArticleDOI
Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes
Sara S. Nunes,Jason W. Miklas,Jie Liu,Roozbeh Aschar-Sobbi,Yun Xiao,Boyang Zhang,Jiahua Jiang,Stéphane Massé,Mark Gagliardi,Anne Hsieh,Nimalan Thavandiran,Michael A. Laflamme,Kumaraswamy Nanthakumar,Gil J. Gross,Peter H. Backx,Peter H. Backx,Gordon Keller,Milica Radisic +17 more
TL;DR: It is demonstrated that the engineered platform allows for the generation of three-dimensional, aligned cardiac tissues (biowires) with frequent striations and that the responses of immature human myocardium to electrical stimulation and pacing are in agreement with cardiomyocyte maturation.
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Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker
Stephanie Protze,Jie Liu,Udi Nussinovitch,Lily Ohana,Lily Ohana,Peter H. Backx,Peter H. Backx,Lior Gepstein,Gordon Keller,Gordon Keller +9 more
TL;DR: A transgene-independent method for the generation of SAN-like pacemaker cells (SANLPCs) from human pluripotent stem cells by stage-specific manipulation of developmental signaling pathways is described, demonstrating their capacity to function as a biological pacemaker.
Journal ArticleDOI
The NAD-dependent deacetylase SIRT2 is required for programmed necrosis
Nisha Narayan,In Hye Lee,Ronen Borenstein,Junhui Sun,Renee Wong,Guang Tong,Guang Tong,Maria M. Fergusson,Jie Liu,Ilsa I. Rovira,Hwei Ling Cheng,Guanghui Wang,Marjan Gucek,David B. Lombard,Fredrick W. Alt,Michael N. Sack,Elizabeth Murphy,Liu Cao,Toren Finkel +18 more
TL;DR: Results implicate SIRT2 as an important regulator of programmed necrosis and indicate that inhibitors of this deacetylase may constitute a novel approach to protect against necrotic injuries, including ischaemic stroke and myocardial infarction.
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Phosphodiesterase Type 3A Regulates Basal Myocardial Contractility Through Interacting With Sarcoplasmic Reticulum Calcium ATPase Type 2a Signaling Complexes in Mouse Heart
Sanja Beca,Faiyaz Ahmad,Weixing Shen,Jie Liu,Samy Makary,Nazari Polidovitch,Junhui Sun,Steven Hockman,Youn Wook Chung,Matthew A. Movsesian,Elizabeth Murphy,Vincent C. Manganiello,Peter H. Backx +12 more
TL;DR: The data support the conclusion that Pde3A is the primary PDE3 isozyme modulating basal contractility and SR Ca2+ content by regulating cAMP in microdomains containing macromolecular complexes of SR calcium ATPase type 2a–phospholamban–PDE3A.
Journal ArticleDOI
The electrophysiological development of cardiomyocytes.
TL;DR: The generation of human cardiomyocytes from human pluripotent stem cells (hPSCs) has become an important resource for modeling human cardiac disease and for drug screening, and also holds significant potential for cardiac regeneration.