Y
Yun Zhang
Researcher at Qilu University of Technology
Publications - 61
Citations - 889
Yun Zhang is an academic researcher from Qilu University of Technology. The author has contributed to research in topics: Zebrafish & Chemistry. The author has an hindex of 11, co-authored 53 publications receiving 343 citations.
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Journal ArticleDOI
Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway
Zhili Jia,Juan Cen,Jia-bo Wang,Feng Zhang,Qing Xia,Xue Wang,Xiqiang Chen,Rongchun Wang,Chung-Der Hsiao,Kechun Liu,Yun Zhang +10 more
TL;DR: INH may act on hepatotoxicity in zebrafish by increasing ROS content, which weakens the antioxidant capacity, leading to ERS, cell apoptosis and liver injury, and the Nrf2 signalling pathway is activated as a stress compensation mechanism during INH-induced liver injury.
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Isoliquiritigenin triggers developmental toxicity and oxidative stress–mediated apoptosis in zebrafish embryos/larvae via Nrf2-HO1/JNK-ERK/mitochondrion pathway
Zhenzhen Song,Yun Zhang,Huazheng Zhang,R. Samuel Rajendran,Rongchun Wang,Chung-Der Hsiao,Jianheng Li,Qing Xia,Kechun Liu +8 more
TL;DR: First evidence that demonstrate ISL-induced dose-dependent developmental toxicity in zebrafish embryos is provided, and gene expression patterns in the embryos correlate the above and reveal potential genetic mechanisms of developmental toxicity.
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Developmental toxicity induced by PM2.5 through endoplasmic reticulum stress and autophagy pathway in zebrafish embryos.
TL;DR: The data indicate that PM2.5 induced a dose- and time-dependent increase in developmental toxicity to zebrafish embryos, and suggests that ERS and autophagy may play important roles in PM 2.5-induced developmental toxicity.
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Xiaoaiping Induces Developmental Toxicity in Zebrafish Embryos Through Activation of ER Stress, Apoptosis and the Wnt Pathway.
TL;DR: Evidence is provided for the first time that XAP can induce dose-related developmental toxicity, and ER stress, apoptosis and the Wnt pathway participate in the toxicity regulation.
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Psoralen Induces Developmental Toxicity in Zebrafish Embryos/Larvae Through Oxidative Stress, Apoptosis, and Energy Metabolism Disorder
Qing Xia,Lingying Wei,Yun Zhang,Haotian Kong,Yongping Shi,Yongping Shi,Xue Wang,Xiqiang Chen,Liwen Han,Kechun Liu +9 more
TL;DR: Results of gene-expression analysis showed that psoralen induced developmental toxicity by means of oxidative stress, apoptosis, and energy metabolism abnormalities showed that Psoralen exerted toxic effects on the developing heart, liver, phagocytes, and nervous system.