Kechun Liu

TL;DR: The results demonstrated that BBR induced a typical hormetic response in PC12 cells, and strongly suggested that the neuroprotection of BBR were attributable to the hormetic mechanisms via activating cell survival and antioxidant signaling pathways.

TL;DR: INH may act on hepatotoxicity in zebrafish by increasing ROS content, which weakens the antioxidant capacity, leading to ERS, cell apoptosis and liver injury, and the Nrf2 signalling pathway is activated as a stress compensation mechanism during INH-induced liver injury.

TL;DR: Low dose PTS could significantly prevent the 6-OHDA-induced dopaminergic neuron loss and improve the behavior movement deficiency in zebrafish, whereas relative high dose PTS exhibited neural toxicity, further supporting the hormetic and neuroprotective effects of PTS.

TL;DR: First evidence that demonstrate ISL-induced dose-dependent developmental toxicity in zebrafish embryos is provided, and gene expression patterns in the embryos correlate the above and reveal potential genetic mechanisms of developmental toxicity.

TL;DR: The results indicated that l-ZnO NRs induced developmental neurotoxicity with hallmarks linked to Parkinson's disease (PD)-like symptoms at relatively high doses, including the disruption of locomotor activity as well as neurodevelopmental and PD responsive genes expression, and the induction of dopaminergic neuronal loss and apoptosis in zebrafish brain.