Xue Wang

TL;DR: INH may act on hepatotoxicity in zebrafish by increasing ROS content, which weakens the antioxidant capacity, leading to ERS, cell apoptosis and liver injury, and the Nrf2 signalling pathway is activated as a stress compensation mechanism during INH-induced liver injury.

TL;DR: The data support the use of the liver area index as a reliable and comparable indicator to screen hepatotoxic agents using the zebrafish model.

TL;DR: Results of gene-expression analysis showed that psoralen induced developmental toxicity by means of oxidative stress, apoptosis, and energy metabolism abnormalities showed that Psoralen exerted toxic effects on the developing heart, liver, phagocytes, and nervous system.

TL;DR: Correlational analyses indicated that the transcription levels of the inflammatory factors interleukin-1b, tumor necrosis factor beta, cyclooxygenase 2 (COX-2), and TNF-ɑ were strongly positively correlated with ALT and AST and ERS and its mediated autophagy and apoptosis pathways might be involved in INH-induced liver injury promoted by inflammation.

TL;DR: Three new diterpenoids, stracheyioids A-C (1-3), as well as 36 known compounds (4-39) were isolated from the whole plants of Euphorbia stracheyi for the first time, and their structures were elucidated on the basis of extensive spectroscopic interpretation.