Y
Yuncheng Man
Researcher at Case Western Reserve University
Publications - 32
Citations - 344
Yuncheng Man is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 6, co-authored 22 publications receiving 131 citations. Previous affiliations of Yuncheng Man include Dalian University of Technology.
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Journal ArticleDOI
Significant Enhancement of the Adhesion between Metal Films and Polymer Substrates by UV–Ozone Surface Modification in Nanoscale
Junshan Liu,Licheng He,Liang Wang,Yuncheng Man,Luyi Huang,Zheng Xu,Dan Ge,Jingmin Li,Chong Liu,Liding Wang +9 more
TL;DR: Detailed characterization results indicate that the significant adhesion enhancement is attributed to the increases of both the surface wettability by generating some polar functional groups and the roughness of the surface in nanoscale.
Journal ArticleDOI
Inhibition of Band 3 tyrosine phosphorylation: a new mechanism for treatment of sickle cell disease
Panae Noomuna,Mary Risinger,Sitong Zhou,Katie Seu,Yuncheng Man,Ran An,Daniel A. Sheik,Jiandi Wan,Jane A. Little,Umut A. Gurkan,Francesco Michelangelo Turrini,Theodosia A. Kalfa,Theodosia A. Kalfa,Philip S. Low +13 more
TL;DR: In view of reports that imatinib (a Syk inhibitor) successfully treats symptoms of sickle cell disease, it is suggested that Syk tyrosine kinase inhibitors warrant repurposing as potential treatments for SCD.
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Microfluidic assessment of red blood cell mediated microvascular occlusion
Yuncheng Man,Erdem Kucukal,Ran An,Quentin D Watson,Jürgen Bosch,Peter A. Zimmerman,Jane A. Little,Umut A. Gurkan +7 more
TL;DR: The promise of OcclusionChip is demonstrated in diverse pathophysiological scenarios that result in impaired RBC deformability, including mercury toxin, storage lesion, end-stage renal disease, malaria, and sickle cell disease (SCD).
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Whole blood viscosity and red blood cell adhesion: Potential biomarkers for targeted and curative therapies in sickle cell disease
Erdem Kucukal,Yuncheng Man,Ailis Hill,Shichen Liu,Allison Bode,Ran An,Jaikrishnan R. Kadambi,Jane A. Little,Umut A. Gurkan +8 more
TL;DR: It is suggested that WBV and RBC adhesion may serve as clinically relevant biomarkers and endpoints in assessing emerging targeted and curative therapies in SCD.
Journal ArticleDOI
Leukocyte adhesion to P-selectin and the inhibitory role of Crizanlizumab in sickle cell disease: A standardized microfluidic assessment.
Yuncheng Man,Utku Goreke,Erdem Kucukal,Ailis Hill,Ran An,Shichen Liu,Allison Bode,Ambar Solis-Fuentes,Lalitha Nayak,Jane A. Little,Umut A. Gurkan +10 more
TL;DR: The results suggest that the microfluidic BioChip system is a promising in vitro assay with which to screen patients, monitor treatment response, and guide current and emerging anti-adhesive therapies in SCD.