L
Lalitha Nayak
Researcher at University Hospitals of Cleveland
Publications - 49
Citations - 1808
Lalitha Nayak is an academic researcher from University Hospitals of Cleveland. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 15, co-authored 38 publications receiving 1165 citations. Previous affiliations of Lalitha Nayak include Case Western Reserve University & University of Louisville.
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Journal ArticleDOI
The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management.
Mouhamed Yazan Abou-Ismail,Mouhamed Yazan Abou-Ismail,Akiva Diamond,Sargam Kapoor,Yasmin Arafah,Lalitha Nayak,Lalitha Nayak +6 more
TL;DR: Of concern, is the observation that anticoagulation may be inadequate in many circumstances, highlighting the need for alternative or additional therapies.
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Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice
Guangjin Zhou,Anne Hamik,Lalitha Nayak,Hongmei Tian,Hong Shi,Yuan Lu,Nikunj Sharma,Xudong Liao,Andrew T. Hale,Lauren M Boerboom,Ryan E. Feaver,Huiyun Gao,Amar Desai,Alvin H. Schmaier,Stanton L. Gerson,Yunmei Wang,G. Brandon Atkins,Brett R. Blackman,Daniel I. Simon,Mukesh K. Jain +19 more
TL;DR: It is shown that endothelial KLF4 is an essential determinant of atherogenesis and thrombosis andMechanistically, it is demonstrated that KLF 4 differentially regulated pertinent endothelial targets via competition for the coactivator p300, and cogent evidence is provided implicated as essential in vivo regulators of vascular function in the adult animal.
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KLF2 and KLF4 control endothelial identity and vascular integrity
Panjamaporn Sangwung,Guangjin Zhou,Lalitha Nayak,E. Ricky Chan,Sandeep Kumar,Dong Won Kang,Rongli Zhang,Xudong Liao,Yuan Lu,Keiki Sugi,Hisashi Fujioka,Hong Shi,Stephanie Lapping,Chandra C. Ghosh,Sarah J. Higgins,Samir M. Parikh,Hanjoong Jo,Hanjoong Jo,Mukesh K. Jain,Mukesh K. Jain +19 more
TL;DR: It is shown that endothelial KLF2 and KLF4 control a large segment of the endothelial transcriptome, thereby affecting virtually all key endothelial functions, and establishing an absolute requirement for KLF 2/4 for maintenance of endothelial and vascular integrity in the adult animal.
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The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock
Ganapati H. Mahabeleshwar,Daiji Kawanami,Nikunj Sharma,Yoichi Takami,Guangjin Zhou,Hong Shi,Lalitha Nayak,Darwin Jeyaraj,Robert Grealy,Mary C. White,Ross McManus,Thomas J. Ryan,Patrick Leahy,Zhiyong Lin,Saptarsi M. Haldar,G. Brandon Atkins,Hector R. Wong,Jerry B. Lingrel,Mukesh K. Jain +18 more
TL;DR: In this paper, the authors identify the Kruppel-like transcription factor 2 (KLF2) as a potent regulator of myeloid cell activation in vivo, and demonstrate that exposure to either hypoxia and/or bacterial products reduced KLF2 expression while inducing hypoxyia inducible factor 1α (HIF-1α), findings that were recapitulated in human septic patients.
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"Go with the flow": how Krüppel-like factor 2 regulates the vasoprotective effects of shear stress.
TL;DR: The identification of Krüppel-like factor 2 as a flow-responsive molecule has greatly advanced the understanding of molecular mechanisms governing vascular homeostasis.