Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. 

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Biomedical polymers: synthesis, properties, and applications

Rational design of AIE-based fluorescent probes for hypochlorite detection in real water samples and live cell imaging.

A naphthalimide-derived hypochlorite fluorescent probe from ACQ to AIE effect transformation.

Facile synthesis of N/B co-doped hierarchically porous carbon materials based on threonine protic ionic liquids for supercapacitor

In the pursuit of high power and energy density electrochemical energy storage technologies, hybrid supercapacitors (HSCs) have drawn increasing research attention due to the combination of the outstanding power density of supercapacitive materials with the high energy density of battery-type materials into a single device. At the same time, many efforts are underway to design effective electrode materials which exhibit good electrical conductivity and abundance, as well as having low cost with easily controllable intrinsic properties. Among various electrode materials, biomass-derived carbon has attracted considerable attention because of the abundance, low cost, environment friendliness and promising electrochemical properties. Furthermore, biomass carbon-based materials in combination with metal oxides/hydroxides with synergetic effects for supercapacitor applications have been a trend in recent years as high-performance electrode materials. Therefore, in this review we focus on the recent progress and current trends in biomass carbon-based composites containing mono-, bi- and trimetallic metal oxides and hydroxides for supercapacitor applications, highlighting the top 5 composites based on mono- and bimetallic oxides and hydroxides. Finally, the prospects and possible future directions are discussed.

Recent progress in and prospects for supercapacitor materials based on metal oxide or hydroxide/biomass-derived carbon composites

Keratin-derived heteroatoms-doped hierarchical porous carbon materials for all-solid flexible supercapacitors

Coronavirus disease 2019 (COVID-19) has rapidly swept around the globe since its emergence near 2020. However, people have failed to fully understand its origin or mutation. Defined as an international biosafety incident, COVID-19 has again encouraged worldwide attention to reconsider the importance of biosafety due to the adverse impact on personal well-being and social stability. Most countries have already taken measures to advocate progress in biosafety-relevant research, aiming to prevent and solve biosafety problems with more advanced techniques and products. Herein, we propose a new concept of biosafety chemistry and reiterate the notion of biosafety materials, which refer to the interdisciplinary integration of biosafety and chemistry or materials. We attempt to illustrate the exquisite association that chemistry and materials science possess with biosafety -science, and we hope to provide a pragmatic perspective on approaches to utilize the knowledge of these two subjects to handle specific biosafety issues, such as detection and disinfection of pathogenic microorganisms, personal protective equipment, vaccine adjuvants and specific drugs, etc.. In addition, we hope to promote multidisciplinary cooperation to strengthen biosafety research and facilitate the development of biosafety products to defend national security in the future. 

https://doi.org/10.1016/j.bsheal.2022.01.001

Biosafety chemistry and biosafety materials: A new perspective to solve biosafety problems

The easily constructed fluorescent probes with excellent sensing performance have attracted increasing attention in recent years. In this work, by virtue of the contrasting light absorption properties of neutral red (NR) and its product NR-NO after the reaction with hypochlorous acid (HOCl) for the fluorescence released from 4-triphenylvinyl-biphenyl (TPEP)-based nanoparticles (T-NPs), a facile inner filter effect (IFE)-based ratiometric sensing platform (SP) was constructed. Upon the addition of HOCl, a typical ratiometric fluorescence change and weak cross-talk between the emission bands (128 nm ≤ Δλem ≤ 182 nm) can be observed from SP, which effectively avoids the spectral overlap and ensures the high sensitivity (LOD = 62 nM) and accuracy in HOCl detection. In addition, because of the good water dispersibility and solubility featured in T-NPs and NR respectively, the SP can also be successfully applied to HOCl detection in 100% aqueous solution and live cell imaging. Moreover, the ratiometric SP avoids the complex covalent linking between fluorophore and energy acceptor, thereby providing great flexibility and convenience for its construction and application.

Yunhao Zhou

Papers

Rational design of AIE-based fluorescent probes for hypochlorite detection in real water samples and live cell imaging.

Keratin-derived heteroatoms-doped hierarchical porous carbon materials for all-solid flexible supercapacitors

Biosafety chemistry and biosafety materials: A new perspective to solve biosafety problems

A facile ratiometric sensing platform based on inner filter effect for hypochlorous acid detection

Prepared carbon dots from wheat straw for detection of Cu2+ in cells and zebrafish and room temperature phosphorescent anti-counterfeiting.