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Yunxia Wang
Researcher at University of California, Berkeley
Publications - 14
Citations - 1215
Yunxia Wang is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Aneuploidy & Leukemia. The author has an hindex of 11, co-authored 14 publications receiving 1195 citations. Previous affiliations of Yunxia Wang include University of Pennsylvania & University of Chicago.
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Journal ArticleDOI
Prevalence of the inactivating 609C-->T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia.
Richard A. Larson,Richard A. Larson,Yunxia Wang,Yunxia Wang,Mekhala Banerjee,Mekhala Banerjee,Joseph L. Wiemels,Joseph L. Wiemels,Christine Hartford,Christine Hartford,Michelle M. Le Beau,Michelle M. Le Beau,Martyn T. Smith,Martyn T. Smith +13 more
TL;DR: The frequency of an inactivating polymorphism in NQO1 appears to be increased in this cohort of myeloid leukemias, especially among those with t-AML or an abnormality of chromosomes 5 and/or 7, which may make them particularly vulnerable to leukedmogenic changes induced by carcinogens.
Journal ArticleDOI
Low NAD(P)H:quinone oxidoreductase 1 activity is associated with increased risk of acute leukemia in adults.
Martyn T. Smith,Martyn T. Smith,Yunxia Wang,Yunxia Wang,Eleanor Kane,Eleanor Kane,Sara Rollinson,Sara Rollinson,Joseph L. Wiemels,Joseph L. Wiemels,Eve Roman,Eve Roman,Philippa L. Roddam,Philippa L. Roddam,Raymond Cartwright,Raymond Cartwright,G. J. Morgan,G. J. Morgan +17 more
TL;DR: In this article, a cysteine-to-threonine (C --> T) substitution polymorphism at nucleotide 609 of the NQO1 complementary DNA (NQO 1 C609T) results in a lowering of the enzyme activity, and individuals homozygous for this mutation have no enzymatic activity and heterozygotes have low to intermediate activity compared with people with wild type.
Journal Article
Increased Translocations and Aneusomy in Chromosomes 8 and 21 Among Workers Exposed to Benzene
Martyn T. Smith,Luoping Zhang,Yunxia Wang,Richard B. Hayes,Guilan Li,Joseph L. Wiemels,Mustafa Dosemeci,Nina Titenko-Holland,Liqiang Xi,Prema Kolachana,Songnian Yin,Nathaniel Rothman +11 more
TL;DR: A potential role for t(8;21) in benzene-induced leukemogenesis is indicated and is consistent with the hypothesis that detection of specific chromosome aberrations may be a powerful approach to identify populations at increased risk of leukemia.
Journal ArticleDOI
Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children
Martyn T. Smith,Martyn T. Smith,Yunxia Wang,Yunxia Wang,Christine F. Skibola,Christine F. Skibola,Diana J. Slater,Diana J. Slater,Luca Lo Nigro,Luca Lo Nigro,Peter C. Nowell,Peter C. Nowell,Beverly J. Lange,Beverly J. Lange,Carolyn A. Felix,Carolyn A. Felix +15 more
TL;DR: The inactivating NQO1 polymorphism is associated with an increased risk of de novo leukemia with MLL translocations in infants and children and the distribution of N QO1 genotypes among patients with treatment-related leukemias with M LL translocations was not statistically different.
Journal ArticleDOI
Increased aneusomy and long arm deletion of chromosomes 5 and 7 in the lymphocytes of Chinese workers exposed to benzene
Luoping Zhang,Nathanial Rothman,Yunxia Wang,Richard B. Hayes,Guilan Li,Mustafa Dosemeci,Songnian Yin,Prema Kolachana,Nina Titenko-Holland,Martyn T. Smith +9 more
TL;DR: It is demonstrated that leukemia-specific changes in chromosomes 5 and 7 can be detected by FISH in the peripheral blood of otherwise healthy benzene-exposed workers, and suggested that aberrations in chromosomes5 and 7 may be useful biomarkers of early biological effect for benzene exposure.