Y
Yutaka Nagai
Researcher at Tokyo Medical and Dental University
Publications - 137
Citations - 4061
Yutaka Nagai is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Collagenase & Type I collagen. The author has an hindex of 35, co-authored 137 publications receiving 4026 citations. Previous affiliations of Yutaka Nagai include Yokohama City University.
Papers
More filters
Journal ArticleDOI
A rapid and micro method for separation of acidic glycosaminoglycans by two-dimensional electrophoresis.
Ryu-Ichiro Hata,Yutaka Nagai +1 more
TL;DR: Electrophoretic separation of seven acidic glycosaminoglycans was accomplished by two-dimensional electrophoresis on a cellulose acetate strip and high resolving power and sensitivity make it possible to identify AGG in tissues in as small amounts as biopsy specimens.
Journal ArticleDOI
Specificity of antibodies to type II collagen in rheumatoid arthritis.
Kuniaki Terato,Kuniaki Terato,Yasunori Shimozuru,Kou Katayama,Yoshiharu Takemitsu,Izumi Yamashita,Makoto Miyatsu,Katsuyuki Fujii,Mitsusada Sagara,Shiegeto Kobayashi,Makoto Goto,Kusuki Nishioka,Nobuyuki Miyasaka,Yutaka Nagai +13 more
TL;DR: Findings indicate that autoantibody formation in RA and relapsing polychondritis may occur as a result of an immune response to heterologous type II collagen, and that the clinical manifestation of collagen autoimmunity might be influenced by the epitope specificity of the antibodies.
Journal ArticleDOI
Studies on the structure of collagen utilizing a collagenolytic enzyme from tadpole.
Journal ArticleDOI
Synthetic substrates for vertebrate collagenase.
TL;DR: Analysis of the degree of hydrolysis of the peptides by tadpole collagenase and human serum peptidase demonstrated that 2,4-dinitrophenyl derivatives of hexa- to octapeptides was the best synthetic substrate for collagenase among the peptide tested.
Journal ArticleDOI
Selective Inhibition of Type I Collagen Synthesis in Osteoblastic Cells by Epidermal Growth Factor
Ryu-Ichiro Hata,Hisae Hori,Yutaka Nagai,Shigeyasu Tanaka,Mayuri Kondo,Masahiko Hiramatsu,Nobuo Utsumi,Masayoshi Kumegawa +7 more
TL;DR: Results indicate that EGF selectively inhibits type I collagen synthesis in the clonal osteoblastic cell line, MC3T3-E1, which is derived from newborn mouse calvaria.