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Yutaka Shimizu
Researcher at Mochida Pharmaceutical Co., Ltd
Publications - 13
Citations - 596
Yutaka Shimizu is an academic researcher from Mochida Pharmaceutical Co., Ltd. The author has contributed to research in topics: Dienogest & Progesterone receptor. The author has an hindex of 11, co-authored 13 publications receiving 515 citations.
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Journal ArticleDOI
Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile
Shinichi Sasagawa,Yutaka Shimizu,Hideaki Kami,Takashi Takeuchi,Shizuka Mita,Kazunori Imada,Shigeaki Kato,Kiyoshi Mizuguchi +7 more
TL;DR: Dienogest showed higher plasma concentrations than those of the other progestins with higher doses and could be explained simply by its in vitro potency on PR and its oral pharmacokinetic profile.
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Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture
Kaoruko Yamanaka,Bing Xu,Izumi Suganuma,Izumi Kusuki,Shizuka Mita,Yutaka Shimizu,Kiyoshi Mizuguchi,Jo Kitawaki +7 more
TL;DR: Because DNG inhibits aromatase and COX-2 expression as well as PGE(2) production in ESCs, these pharmacologic features might contribute to a therapeutic effect of DNG on endometriosis.
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Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system.
TL;DR: The findings suggest that the pharmacological mechanism of dienogest includes the direct inhibition of PGE(2) synthase and aromatase expression and may contribute to the therapeutic effect on the progression of endometriosis.
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Eicosapentaenoic acid attenuates progression of hepatic fibrosis with inhibition of reactive oxygen species production in rats fed methionine- and choline-deficient diet.
Satoshi Kajikawa,Kazunori Imada,Takashi Takeuchi,Yutaka Shimizu,Akiko Kawashima,Tsuyoshi Harada,Kiyoshi Mizuguchi +6 more
TL;DR: EPA-E attenuates progression of hepatic fibrosis in developed steatohepatitis, and this effect is likely mediated by inhibition of ROS production, which may elicit the therapeutic effect of EPA-E against NASH.
Journal ArticleDOI
Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin D1 gene expression.
Yutaka Shimizu,Takashi Takeuchi,Shizuka Mita,Kiyoshi Mizuguchi,Tohru Kiyono,Masaki Inoue,Satoru Kyo +6 more
TL;DR: It is suggested that dienogest directly inhibits the proliferation of human endometrial epithelial cells with suppression of cyclin D1 gene expression.