K
Kazunori Imada
Researcher at Mochida Pharmaceutical Co., Ltd
Publications - 26
Citations - 808
Kazunori Imada is an academic researcher from Mochida Pharmaceutical Co., Ltd. The author has contributed to research in topics: Eicosapentaenoic acid & Docosahexaenoic acid. The author has an hindex of 17, co-authored 26 publications receiving 726 citations.
Papers
More filters
Journal ArticleDOI
Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile
Shinichi Sasagawa,Yutaka Shimizu,Hideaki Kami,Takashi Takeuchi,Shizuka Mita,Kazunori Imada,Shigeaki Kato,Kiyoshi Mizuguchi +7 more
TL;DR: Dienogest showed higher plasma concentrations than those of the other progestins with higher doses and could be explained simply by its in vitro potency on PR and its oral pharmacokinetic profile.
Journal ArticleDOI
Highly purified eicosapentaenoic acid prevents the progression of hepatic steatosis by repressing monounsaturated fatty acid synthesis in high-fat/high-sucrose diet-fed mice
TL;DR: Oral administration of EPA-E ameliorates hepatic fat accumulation by suppressing TG synthesis enzymes regulated by SREBP-1 and decreases hepatic MUFAs accumulation by SCD1.
Journal ArticleDOI
Palmitic Acid Induces Osteoblastic Differentiation in Vascular Smooth Muscle Cells through ACSL3 and NF-κB, Novel Targets of Eicosapentaenoic Acid
Aiko Kageyama,Hiroki Matsui,Hiroki Matsui,Masahiko Ohta,Keisuke Sambuichi,Hiroyuki Kawano,Tatsuto Notsu,Kazunori Imada,Tomoyuki Yokoyama,Masahiko Kurabayashi +9 more
TL;DR: ACSL3 and NF-κB are identified as mediators of PA-induced osteoblastic differentiation and calcium deposition in VSMC and it is suggested that EPA prevents vascular calcification by inhibiting such a new molecular pathway elicited by PA.
Journal ArticleDOI
Effects of eicosapentaenoic acid on synaptic plasticity, fatty acid profile and phosphoinositide 3-kinase signaling in rat hippocampus and differentiated PC12 cells
TL;DR: The findings suggest that EPA protects against neurodegeneration by modulating synaptic plasticity and activating the PI3-kinase/Akt pathway, possibly by its own functional effects in neurons and glial cells and by its capacity to increase brain docosahexaenoic acid.
Journal ArticleDOI
Eicosapentaenoic acid attenuates progression of hepatic fibrosis with inhibition of reactive oxygen species production in rats fed methionine- and choline-deficient diet.
Satoshi Kajikawa,Kazunori Imada,Takashi Takeuchi,Yutaka Shimizu,Akiko Kawashima,Tsuyoshi Harada,Kiyoshi Mizuguchi +6 more
TL;DR: EPA-E attenuates progression of hepatic fibrosis in developed steatohepatitis, and this effect is likely mediated by inhibition of ROS production, which may elicit the therapeutic effect of EPA-E against NASH.