Yuzuru Imai

TL;DR: It is reported that a reduction in TDP-43 protein levels alleviates the synaptic defects of neurons expressing the Perry mutant p150G50R in Drosophila, suggesting that the stagnation of axonal transport by dynactin mutations promotes T DP-43 aggregation and interferes with the dynamics of DCVs and synaptic activities.

TL;DR: In this article, Parkin's Parkin substrate was used to identify a factor causative of Parkinson's disease with the use of the substrate and a method of screening a remedy for Parkinson's Disease by using the same.

TL;DR: itin (Ub) kinase PINK1 and the E3 Ub ligase Parkin, two gene products associated with young-onset Parkinson's disease, and phospho-Ub signaling and the relocation of axonal mitochondria upon ΔΨm reduction are indeed compromised in human dopaminergic neurons containing Parkin or Pink1 mutations are examined.

TL;DR: The results suggest that apoptosis occurs in granulosa cells but not cumulus cells in the atretic antral follicles in pigs, and ICE like protease (s) is involved in intracellular signal transmission ofgranulosa cell apoptosis of the at retic Antral follicle in pigs.

TL;DR: In this paper, the authors investigated the endogenous function of UQCRC1 in the human neuronal cell line and the Drosophila nervous system and identified a role for UqCRC 1 in regulating cyt-c-induced apoptosis.