C
Chin-Hsien Lin
Researcher at National Taiwan University
Publications - 177
Citations - 4579
Chin-Hsien Lin is an academic researcher from National Taiwan University. The author has contributed to research in topics: Population & Parkinsonism. The author has an hindex of 33, co-authored 152 publications receiving 3492 citations. Previous affiliations of Chin-Hsien Lin include National Taiwan Ocean University & Academia Sinica.
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Journal ArticleDOI
Minimal Detectable Change of the Timed “Up & Go” Test and the Dynamic Gait Index in People With Parkinson Disease
TL;DR: The results showed that the TUG and the DGI have generally acceptable random measurement error and test-retest reliability, which should help clinicians and researchers determine whether a change in an individual patient with PD is a true change.
Journal ArticleDOI
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.
Owen A. Ross,Alexandra I. Soto-Ortolaza,Michael G. Heckman,Jan O. Aasly,Nadine Abahuni,Grazia Annesi,Justin A. Bacon,Soraya Bardien,Maria Bozi,Alexis Brice,Laura Brighina,Christine Van Broeckhoven,Christine Van Broeckhoven,Jonathan Carr,Marie-Christine Chartier-Harlin,Marie-Christine Chartier-Harlin,Efthimios Dardiotis,Efthimios Dardiotis,Dennis W. Dickson,Nancy N. Diehl,Alexis Elbaz,Alexis Elbaz,Carlo Ferrarese,Alessandro Ferraris,Brian K. Fiske,J. Mark Gibson,Rachel A. Gibson,Georgios M. Hadjigeorgiou,Georgios M. Hadjigeorgiou,Nobutaka Hattori,John P. A. Ioannidis,John P. A. Ioannidis,Barbara Jasinska-Myga,Beom S. Jeon,Yun Joong Kim,Christine Klein,Rejko Krüger,Elli Kyratzi,Suzanne Lesage,Suzanne Lesage,Suzanne Lesage,Chin-Hsien Lin,Timothy Lynch,Demetrius M. Maraganore,George D. Mellick,Eugénie Mutez,Eugénie Mutez,Christer Nilsson,Grzegorz Opala,Sung Sup Park,Andreas Puschmann,Aldo Quattrone,Manu Sharma,Peter A. Silburn,Young H. Sohn,Leonidas Stefanis,Vera Tadic,Jessie Theuns,Jessie Theuns,Hiroyuki Tomiyama,Ryan J. Uitti,Enza Maria Valente,Simone Van De Loo,Demetrios K. Vassilatis,Carles Vilariño-Güell,Linda R. White,Karin Wirdefeldt,Zbigniew K. Wszolek,Ruey-Meei Wu,Matthew J. Farrer,Matthew J. Farrer +70 more
TL;DR: The results for LRRK2 show that several rare and common genetic variants in the same gene can have independent effects on disease risk, and are important in the cause and pathogenesis of PD in a greater proportion of patients with this disease than previously believed.
Journal ArticleDOI
Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson’s disease
Chin-Hsien Lin,Chieh-Chang Chen,Han-Lin Chiang,Jyh-Ming Liou,C. Y. Chang,Tzu-Pin Lu,Eric Y. Chuang,Yi-Cheng Tai,Chieh Cheng,Han-Yi Lin,Ming-Shiang Wu +10 more
TL;DR: This study reveals altered gut microbiota in PD and its correlation with clinical phenotypes and severity in the authors' population and suggests aberrant immune responses may contribute to inflammatory processes in PD.
Journal ArticleDOI
Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia
Matthew J. Farrer,Jeremy T. Stone,Chin-Hsien Lin,Justus C. Dachsel,Mary M. Hulihan,Kristoffer Haugarvoll,Owen A. Ross,Ruey-Meei Wu +7 more
TL;DR: It is suggested that Lrrk2 G2385R carriers originate from one ancestor some 4800 years ago, at the start of Chinese civilization, which may have important implications for future genome-wide association studies.
Journal ArticleDOI
LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3β
TL;DR: It is found that expression of G2019S mutant in Drosophila dendritic arborization neurons induces mislocalization of the axonal protein tau in dendrites and causes dendrite degeneration.