Yves Deshaies

TL;DR: It is proposed that adiponectin acts as a peripheral "starvation" signal promoting the storage of triglycerides preferentially in adipose tissue, and reduced triglyceride levels in the liver and muscle convey improved systemic insulin sensitivity.

TL;DR: It is suggested that increasing endogenous adiponectin levels has direct effects on insulin sensitivity and may induce similar physiological responses as prolonged treatment with peroxisomal proliferator-activated receptor gamma agonists.

TL;DR: The findings unravel a novel mechanism by which mTORC1/S6K1 controls gluconeogenesis through modulation of several key transcriptional factors and underlies the development of severe glucose intolerance even in the face of preserved hepatic insulin signaling to Akt and despite a modest reduction in adiposity.

TL;DR: It is demonstrated that effective treatment of a maternal phenotype is durably detectable in the methylome and transcriptome of subsequent offspring, reflected in genes involved in diabetes-related cardiometabolic pathways.

TL;DR: Uncoupling protein 1 expression is modulated by diet and metabolic hormones such as leptin and glucocorticoids, which suggests that the protein is a player in energy balance regulation.