S
Susanna M. Hofmann
Researcher at University of Cincinnati
Publications - 54
Citations - 5062
Susanna M. Hofmann is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Insulin resistance & Internal medicine. The author has an hindex of 27, co-authored 43 publications receiving 4384 citations. Previous affiliations of Susanna M. Hofmann include University of Cincinnati Academic Health Center & Helmholtz Zentrum München.
Papers
More filters
Journal ArticleDOI
Obesity-associated improvements in metabolic profile through expansion of adipose tissue
Ja Young Kim,Esther Van De Wall,Mathieu Laplante,Anthony Azzara,Maria E. Trujillo,Susanna M. Hofmann,Todd Schraw,Jorge L. Durand,Hua Li,Guangyu Li,Linda A. Jelicks,Mark F. Mehler,David Y. Hui,Yves Deshaies,Gerald I. Shulman,Gary J. Schwartz,Philipp E. Scherer +16 more
TL;DR: It is proposed that adiponectin acts as a peripheral "starvation" signal promoting the storage of triglycerides preferentially in adipose tissue, and reduced triglyceride levels in the liver and muscle convey improved systemic insulin sensitivity.
Journal ArticleDOI
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
Jonathan Day,Nickki Ottaway,James Patterson,Vasily M. Gelfanov,David L. Smiley,Jas Gidda,Hannes M. Findeisen,Dennis Bruemmer,Daniel J. Drucker,Nilika Chaudhary,Jenna Holland,Jazzminn Hembree,William Abplanalp,Erin Grant,Jennifer Ruehl,Hilary Wilson,Henriette Kirchner,Sarah Kathleen Haas Lockie,Susanna M. Hofmann,Stephen C. Woods,Rubén Nogueiras,Paul T. Pfluger,Diego Perez-Tilve,Richard D. DiMarchi,Matthias H. Tschöp +24 more
TL;DR: Preclinical studies indicate that when full GLP-1 agonism is augmented with an appropriate degree of glucagon receptor activation, body fat reduction can be substantially enhanced without any overt adverse effects.
Journal ArticleDOI
The central melanocortin system directly controls peripheral lipid metabolism
Rubén Nogueiras,Petra Wiedmer,Diego Perez-Tilve,Christelle Veyrat-Durebex,Julia M. Keogh,Gregory M. Sutton,Paul T. Pfluger,Tamara R. Castañeda,Susanne Neschen,Susanna M. Hofmann,Philip N. Howles,Donald A. Morgan,Stephen C. Benoit,Ildiko Szanto,Brigitte Schrott,Annette Schürmann,Hans-Georg Joost,Craig Hammond,David Y. Hui,Stephen C. Woods,Kamal Rahmouni,Andrew A. Butler,I. Sadaf Farooqi,Stephen O'Rahilly,Françoise Rohner-Jeanrenaud,Matthias H. Tschöp +25 more
TL;DR: Pharmacological inhibition of melanocortin receptors in rats and genetic disruption of Mc4r in mice directly and potently promoted lipid uptake, triglyceride synthesis, and fat accumulation in white adipose tissue (WAT), while increased CNS-Mcr signaling triggered lipid mobilization.
Journal ArticleDOI
Improved Insulin Sensitivity Is Associated With Restricted Intake of Dietary Glycoxidation Products in the db/db Mouse
Susanna M. Hofmann,H. Henry Dong,Zhu Li,Weijing Cai,Jennifer Altomonte,Swan N. Thung,Feng Zeng,Edward A. Fisher,Helen Vlassara +8 more
TL;DR: It is demonstrated that reduced AGE intake leads to lower levels of circulating AGE and to improved insulin sensitivity in db/db mice, and LAD-fed mice presented a better-preserved structure of the islets.
Journal ArticleDOI
Diabetes-Induced Oxidative Stress and Low-Grade Inflammation in Porcine Coronary Arteries
LiFeng Zhang,Andrew A. Zalewski,Yuchuan Liu,Tomasz Mazurek,Scott W. Cowan,Jack L. Martin,Susanna M. Hofmann,Helen Vlassara,Yi Shi +8 more
TL;DR: The involvement of AGEs in the development of accelerated coronary atherosclerosis in diabetes is suggested, as well as the mechanisms of abnormal formation of reactive oxygen species and the changes in inflammatory gene expression examined.