Zachary Freyberg

TL;DR: Evidence that Akt/GSK-3 and Wnt-related pathways are involved in the pathogenesis of schizophrenia as well as details of intracellular events related to these molecules mediated by both typical and atypical antipsychotic medications are reviewed.

TL;DR: The hypothesis that, even in mammalian cells, amphiphysin/Rvs family members have a role both in endocytosis and in actin function is supported and it is suggested that distinct amphiphYSin isoforms contribute to define distinct domains of the cortical cytoplasm.

TL;DR: The data show that the intracellular localization of PLD1 is consistent with a role in vesicle trafficking from the Golgi apparatus and suggest that it also functions in the cell nucleus.

TL;DR: It is shown that C99, in addition to its localization in endosomes, can also be found in MAM, where it is normally processed rapidly by γ‐secretase, and this change in mitochondrial membrane composition interferes with the proper assembly and activity of mitochondrial respiratory supercomplexes, thereby likely contributing to the bioenergetic defects characteristic of AD.

TL;DR: This work reviews targeted approaches for pharmacotherapy involving the glutamatergic, GABAergic and cholinergic pathways, and describes several of the major genetic findings that identify signaling pathways representing potential targets for novel pharmacological intervention.