Robin B. Chan

TL;DR: In this paper, a system-based approach was employed to determine the lipidome of brain tissues affected by Alzheimer disease using liquid chromatography-mass spectrometry to profile extracts from the prefrontal cortex, entorhinal cortex, and cerebellum of late-onset AD patients.

TL;DR: Overall, these results suggest that HIV-1 and other retroviruses bud from cholesterol-rich regions of the plasma membrane and exploit matrix/PI(4,5)P2 interactions for particle release from cells.

TL;DR: Phosphatidylinositol-3-phosphate deficiency is established as a contributing factor in Alzheimer's disease and the mechanisms of amyloid precursor protein trafficking through the endosomal system in normal and pathological states are clarified.

TL;DR: It is shown that oligomeric Aβ enhances PLD activity in cultured neurons and that this stimulatory effect does not occur upon ablation of PLD2 via gene targeting, which points to specific molecular species of PA as key modulators of AD pathogenesis and identifies PLD 2 as a novel potential target for therapeutics.

TL;DR: It is shown that C99, in addition to its localization in endosomes, can also be found in MAM, where it is normally processed rapidly by γ‐secretase, and this change in mitochondrial membrane composition interferes with the proper assembly and activity of mitochondrial respiratory supercomplexes, thereby likely contributing to the bioenergetic defects characteristic of AD.