Z
Zaki A. Naserullah
Researcher at King Faisal University
Publications - 16
Citations - 225
Zaki A. Naserullah is an academic researcher from King Faisal University. The author has contributed to research in topics: Haplotype & Fetal hemoglobin. The author has an hindex of 9, co-authored 14 publications receiving 197 citations. Previous affiliations of Zaki A. Naserullah include Boston Children's Hospital & University of Dammam.
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Journal ArticleDOI
Fetal Hemoglobin in Sickle Cell Anemia: Genetic Studies of the Arab-Indian Haplotype
Duyen A. Ngo,Harold Bae,Martin H. Steinberg,Paola Sebastiani,Nadia Solovieff,Clinton T. Baldwin,Efthymia Melista,Surinder Safaya,Lindsay A. Farrer,Ahmed M. Al-Suliman,Waleed H. Albuali,Muneer H. Al Bagshi,Zaki A. Naserullah,Idowu Akinsheye,Patrick G. Gallagher,Hong-Yuan Luo,David H.K. Chui,John J. Farrell,Amein K. Al-Ali,Abdulrahman Alsultan +19 more
TL;DR: The dispersion of HbF levels among AI haplotype patients suggests that other genetic elements modulate the effects of the known cis- and trans-acting regulators.
Journal ArticleDOI
BCL11A enhancer haplotypes and fetal hemoglobin in sickle cell anemia
Paola Sebastiani,John J. Farrell,Abdulrahman Alsultan,Shuai Wang,Heather L. Edward,Heather Shappell,Harold Bae,Jacqueline N. Milton,Clinton T. Baldwin,Abdullah M. Al-Rubaish,Zaki A. Naserullah,Fahad Al-Muhanna,Ahmed M. Al-Suliman,P.K. Patra,Lindsay A. Farrer,Duyen A. Ngo,Vinod Vathipadiekal,David H.K. Chui,Amein K. Al-Ali,Martin H. Steinberg +19 more
TL;DR: Common HBF BCL11A enhancer haplotypes in patients with African origin and AI sickle cell anemia have similar effects on HbF but they do not explain their differences in HfF.
Journal ArticleDOI
A novel HBA2 gene conversion in cis or trans: "α12 allele" in a Saudi population.
J. Francis Borgio,Sayed AbdulAzeez,Awatif N. Al-Nafie,Zaki A. Naserullah,Sana Al-Jarrash,Mohammed S. Al-Madan,Fahad Al-Muhanna,Martin H. Steinberg,Amein K. Al-Ali +8 more
TL;DR: Direct sequencing of the HBA2 and HBA1 genes from 157 Saudi subjects revealed a new HBA 2 gene conversion in cis or trans in 5.7% of the total, referred to as an α12 (HBA12) allele due to its combination of α1 (H BA1) and α2 (Hba2) sequences.
Journal ArticleDOI
Hemoglobin A2 (HbA2) has a measure of unreliability in diagnosing β-thalassemia trait (β-TT).
Amani M. Al-Amodi,Neda Z. Ghanem,Sumayh A Aldakeel,Lubna Ibrahim Al Asoom,Nazish Rafique Ahmed,Noor B. Almandil,Zaki A. Naserullah,Sana Al-Jarrash,Mohammed Shakil Akhtar,Sayed AbdulAzeez,Amein K. Al-Ali,J. Francis Borgio +11 more
TL;DR: HbA2 has a measure of unreliability in the diagnosis of β-thalassemia carriers, and can be incorrectly diagnosed as carriers.
Journal ArticleDOI
A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia.
Vinod Vathipadiekal,John J. Farrell,Shuai Wang,Heather L. Edward,Heather Shappell,Abdullah M. Al-Rubaish,Fahad Al-Muhanna,Zaki A. Naserullah,Ahmed M. Al-Suliman,Hatem O. Qutub,Irene Simkin,Lindsay A. Farrer,Zhihua Jiang,Hong-Yuan Luo,Shengwen Huang,Gustavo Mostoslavsky,George J. Murphy,P.K. Patra,David H.K. Chui,Abdulrahman Alsultan,Amein K. Al-Ali,Paola Sebastiani,Martin H. Steinberg +22 more
TL;DR: An intronic single nucleotide polymorphism in ANTXR1, an anthrax toxin receptor (chromosome 2p13), contributes to the variation in HbF in Saudi AI haplotype sickle cell anemia and is the first gene in trans to HBB that is associated with HBF only in carriers of the SaudiAI haplotype.