P
Patrick G. Gallagher
Researcher at Yale University
Publications - 287
Citations - 11749
Patrick G. Gallagher is an academic researcher from Yale University. The author has contributed to research in topics: Gene & Spectrin. The author has an hindex of 52, co-authored 280 publications receiving 10279 citations. Previous affiliations of Patrick G. Gallagher include National Institutes of Health & St. Elizabeth Hospital.
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Journal ArticleDOI
Red cell membrane: past, present, and future
TL;DR: The current concept of the red cell membrane envisions it as a composite structure in which a membrane envelope composed of cholesterol and phospholipids is secured to an elastic network of skeletal proteins via transmembrane proteins.
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Seventy-Five Years of Neonatal Sepsis at Yale: 1928–2003
TL;DR: The demographics, pathogens, and outcome associated with neonatal sepsis continue to change, and a marked increase in cases as a result of commensal species was observed in preterm infants who had indwelling central vascular catheters, were receiving parenteral nutrition, and required prolonged mechanical ventilation.
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Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis
Ryan Zarychanski,Vincent P. Schulz,Brett L. Houston,Yelena Maksimova,Donald S. Houston,Brian H. Smith,Jesse Rinehart,Patrick G. Gallagher +7 more
TL;DR: Findings, the first report of mutation in a mammalian mechanosensory transduction channel-associated with genetic disease, suggest that PIEZO proteins play an important role in maintaining erythrocyte volume homeostasis.
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Global transcriptome analyses of human and murine terminal erythroid differentiation
Xiuli An,Xiuli An,Vincent P. Schulz,Jie Li,Kunlu Wu,Kunlu Wu,Jing Liu,Jing Liu,Fumin Xue,Jingping Hu,Narla Mohandas,Patrick G. Gallagher +11 more
TL;DR: Clustering and network analyses revealed that varying stage-specific patterns of expression observed across differentiation were enriched for genes of differing function, and tight clustering of transcriptomes from differing stages, even between biologically different replicates, validated the utility of the FACS-based assays.
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Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity
Jesse Rinehart,Yelena Maksimova,Jessica E. Tanis,Kathryn L. Stone,Caleb A. Hodson,Junhui Zhang,Mary Risinger,Weijun Pan,Dianqing Wu,Christopher M. Colangelo,Biff Forbush,Clinton H. Joiner,Erol E. Gulcicek,Patrick G. Gallagher,Richard P. Lifton +14 more
TL;DR: Two sites in KCC3 that are rapidly dephosphorylated in hypotonic conditions in cultured cells and human red blood cells in parallel with increased transport activity are identified, providing insight into regulation of [Cl(-)](i) and have implications for control of cell volume and neuronal function.